Dihydrochalcone
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Hodoodo CAT#: H592134

CAS#: 1083-30-3

Description: Dihydrochalcone Cognitive Deficits and Neuropathology. It is also known to reduced periplaque activated microglia and astrocytes, indicating the inhibition of neuroinflammation.

Chemical Structure

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Dihydrochalcone
CAS# 1083-30-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H592134
Name: Dihydrochalcone
CAS#: 1083-30-3
Chemical Formula: C15H14O
Exact Mass: 210.10
Molecular Weight: 210.276
Elemental Analysis: C, 85.68; H, 6.71; O, 7.61

Price and Availability

Size Price Availability Quantity
1g USD 250 2 Weeks
5g USD 650 2 weeks
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Synonym: Dihydrochalcone

IUPAC/Chemical Name: 1-Propanone, 1,3-diphenyl-

InChi Key: QGGZBXOADPVUPN-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H14O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-10H,11-12H2

SMILES Code: O=C(C1=CC=CC=C1)CCC2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 210.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yang W, Zhou K, Zhou Y, An Y, Hu T, Lu J, Huang S, Pei G. Naringin Dihydrochalcone Ameliorates Cognitive Deficits and Neuropathology in APP/PS1 Transgenic Mice. Front Aging Neurosci. 2018 Jun 5;10:169. doi: 10.3389/fnagi.2018.00169. eCollection 2018. PubMed PMID: 29922152; PubMed Central PMCID: PMC5996202.

2: Jin Y, Sun Y, Lei J, Wei G. Dihydrochalcone molecules destabilize Alzheimer's amyloid-β protofibrils through binding to the protofibril cavity. Phys Chem Chem Phys. 2018 Jun 27;20(25):17208-17217. doi: 10.1039/c8cp01631c. PubMed PMID: 29900443.

3: Zopun M, Lieder B, Holik AK, Ley JP, Hans J, Somoza V. Noncaloric Sweeteners Induce Peripheral Serotonin Secretion via the T1R3-Dependent Pathway in Human Gastric Parietal Tumor Cells (HGT-1). J Agric Food Chem. 2018 Jun 25. doi: 10.1021/acs.jafc.8b02071. [Epub ahead of print] PubMed PMID: 29874909.

4: Kurahayashi K, Hanaya K, Higashibayashi S, Sugai T. Synthesis of trilobatin from naringin via prunin as the key intermediate: acidic hydrolysis of the α-rhamnosidic linkage in naringin under improved conditions. Biosci Biotechnol Biochem. 2018 Jun 4:1-5. doi: 10.1080/09168451.2018.1482455. [Epub ahead of print] PubMed PMID: 29865928.

5: Yin S, Zhang X, Lai F, Liang T, Wen J, Lin W, Qiu J, Liu S, Li L. Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope. FEBS Lett. 2018 May 26. doi: 10.1002/1873-3468.13113. [Epub ahead of print] PubMed PMID: 29802645.

6: Li X, Chen B, Xie H, He Y, Zhong D, Chen D. Antioxidant Structure⁻Activity Relationship Analysis of Five Dihydrochalcones. Molecules. 2018 May 12;23(5). pii: E1162. doi: 10.3390/molecules23051162. PubMed PMID: 29757201.

7: Tsunekawa R, Hanaya K, Higashibayashi S, Sugai T. Synthesis of fisetin and 2',4',6'-trihydroxydihyrochalcone 4'-O-β-neohesperidoside based on site-selective deacetylation and deoxygenation. Biosci Biotechnol Biochem. 2018 Apr 26:1-7. doi: 10.1080/09168451.2018.1467263. [Epub ahead of print] PubMed PMID: 29699439.

8: Payne JN, Badwaik VD, Waghwani HK, Moolani HV, Tockstein S, Thompson DH, Dakshinamurthy R. Development of dihydrochalcone-functionalized gold nanoparticles for augmented antineoplastic activity. Int J Nanomedicine. 2018 Mar 28;13:1917-1926. doi: 10.2147/IJN.S143506. eCollection 2018. PubMed PMID: 29636609; PubMed Central PMCID: PMC5880570.

9: Montenegro I, Madrid A. Synthesis of dihydroisorcordoin derivatives and their in vitro anti-oomycete activities. Nat Prod Res. 2018 Apr 5:1-4. doi: 10.1080/14786419.2018.1460828. [Epub ahead of print] PubMed PMID: 29620446.

10: Johnson R, Beer D, Dludla PV, Ferreira D, Muller CJF, Joubert E. Aspalathin from Rooibos (Aspalathus linearis): A Bioactive C-glucosyl Dihydrochalcone with Potential to Target the Metabolic Syndrome. Planta Med. 2018 Jul;84(9-10):568-583. doi: 10.1055/s-0044-100622. Epub 2018 Jan 31. PubMed PMID: 29388183.

11: Paravisini L, Peterson DG. Role of Reactive Carbonyl Species in non-enzymatic browning of apple juice during storage. Food Chem. 2018 Apr 15;245:1010-1017. doi: 10.1016/j.foodchem.2017.11.071. Epub 2017 Nov 21. PubMed PMID: 29287316.

12: Zhou K, Hu L, Li P, Gong X, Ma F. Genome-wide identification of glycosyltransferases converting phloretin to phloridzin in Malus species. Plant Sci. 2017 Dec;265:131-145. doi: 10.1016/j.plantsci.2017.10.003. Epub 2017 Oct 10. PubMed PMID: 29223335.

13: Ibdah M, Martens S, Gang DR. Biosynthetic Pathway and Metabolic Engineering of Plant Dihydrochalcones. J Agric Food Chem. 2018 Mar 14;66(10):2273-2280. doi: 10.1021/acs.jafc.7b04445. Epub 2017 Dec 11. Review. PubMed PMID: 29171271.

14: Zheng W, Chen C, Zhang C, Cai L, Chen H. The protective effect of phloretin in osteoarthritis: an in vitro and in vivo study. Food Funct. 2018 Jan 24;9(1):263-278. doi: 10.1039/c7fo01199g. PubMed PMID: 29168867.

15: Sun CQ, Johnson KD, Wong H, Foo LY. Biotransformation of Flavonoid Conjugates with Fatty Acids and Evaluations of Their Functionalities. Front Pharmacol. 2017 Nov 2;8:759. doi: 10.3389/fphar.2017.00759. eCollection 2017. PubMed PMID: 29163154; PubMed Central PMCID: PMC5673637.

16: Du L, Jiang Z, Xu L, Zhou N, Shen J, Dong Z, Shen L, Wang H, Luo X. Microfluidic reactor for lipase-catalyzed regioselective synthesis of neohesperidin ester derivatives and their antimicrobial activity research. Carbohydr Res. 2018 Jan 2;455:32-38. doi: 10.1016/j.carres.2017.11.008. Epub 2017 Nov 21. PubMed PMID: 29161612.

17: Reyes MM, Castura JC, Hayes JE. Characterizing Dynamic Sensory Properties of Nutritive and Nonnutritive Sweeteners with Temporal Check-All-That-Apply. J Sens Stud. 2017 Jun;32(3). pii: e12270. doi: 10.1111/joss.12270. Epub 2017 May 20. PubMed PMID: 29104366; PubMed Central PMCID: PMC5665403.

18: Kostrzewa-Susłow E, Dymarska M, Guzik U, Wojcieszyńska D, Janeczko T. Stenotrophomonas maltophilia: A Gram-Negative Bacterium Useful for Transformations of Flavanone and Chalcone. Molecules. 2017 Oct 27;22(11). pii: E1830. doi: 10.3390/molecules22111830. PubMed PMID: 29077064.

19: Jeong GH, Cho JH, Kim SH, Kim TH. Plasma-induced dimerization of phloridzin as a new class of anti-adipogenic agents. Bioorg Med Chem Lett. 2017 Nov 1;27(21):4889-4892. doi: 10.1016/j.bmcl.2017.09.035. Epub 2017 Sep 18. PubMed PMID: 28958622.

20: Johnson R, Shabalala S, Louw J, Kappo AP, Muller CJF. Aspalathin Reverts Doxorubicin-Induced Cardiotoxicity through Increased Autophagy and Decreased Expression of p53/mTOR/p62 Signaling. Molecules. 2017 Sep 22;22(10). pii: E1589. doi: 10.3390/molecules22101589. PubMed PMID: 28937626.