WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558399
CAS#: 1395048-49-3
Description: M-110 is a inhibitor of protein arginine N-methyltransferases (PRMTs). It is also a highly isoform-selective, cell permeable and potent ATP-competitive inhibitor of the PIM kinase family that prefers PIM-3, shown to inhibit the proliferation of prostate cancer cell lines with IC50s between 0.6 to 0.9 μM, with no activity on normal human peripheral blood mononuclear cells up to 40 μM.
Hodoodo Cat#: H558399
Name: M-110
CAS#: 1395048-49-3
Chemical Formula: C22H28ClN5O3
Exact Mass: 445.19
Molecular Weight: 445.948
Elemental Analysis: C, 59.25; H, 6.33; Cl, 7.95; N, 15.70; O, 10.76
Synonym: M-110; M 110; M110;
IUPAC/Chemical Name: (E)-2-(3-Morpholin-4-yl-propylamino)-isonicotinic acid [1-(4-chloro-2-hydroxy-phenyl)-propylidene]-hydrazide
InChi Key: FXXCNYVQIONABS-LGUFXXKBSA-N
InChi Code: InChI=1S/C22H28ClN5O3/c1-2-19(18-5-4-17(23)15-20(18)29)26-27-22(30)16-6-8-25-21(14-16)24-7-3-9-28-10-12-31-13-11-28/h4-6,8,14-15,29H,2-3,7,9-13H2,1H3,(H,24,25)(H,27,30)/b26-19+
SMILES Code: O=C(N/N=C(C1=CC=C(Cl)C=C1O)\CC)C2=CC=NC(NCCCN3CCOCC3)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 445.95 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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