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Inosine
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H592255

CAS#: 58-63-9 (free base)

Description: Inosine is a purine nucleoside that has hypoxanthine linked by the N9 nitrogen to the C1 carbon of ribose. It is an intermediate in the degradation of purines and purine nucleosides to uric acid and in pathways of purine salvage. It also occurs in the anticodon of certain transfer RNA molecules.

Chemical Structure

Inosine

CAS# 58-63-9 (free base)

Instruction

Theoretical Analysis

Hodoodo Cat#: H592255
Name: Inosine
CAS#: 58-63-9 (free base)
Chemical Formula: C10H12N4O5
Exact Mass: 268.08
Molecular Weight: 268.230
Elemental Analysis: C, 44.78; H, 4.51; N, 20.89; O, 29.82

Price and Availability

Size	Price	Availability
5g	USD 250	2 Weeks
25g	USD 450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Inosine; NSC 20262; NSC-20262; NSC20262

IUPAC/Chemical Name: Inosine

InChi Key: UGQMRVRMYYASKQ-KQYNXXCUSA-N

InChi Code: InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6-,7-,10-/m1/s1

SMILES Code: OC[C@@H]1[C@H]([C@H]([C@H](N2C=NC3=C(N=CN=C32)O)O1)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Soluble in DMSO	0.0	0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 268.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006-. Available from http://www.ncbi.nlm.nih.gov/books/NBK501543/ PubMed PMID: 30000603.

2: Shanmugam R, Zhang F, Srinivasan H, Charles Richard JL, Liu KI, Zhang X, Woo CWA, Chua ZHM, Buschdorf JP, Meaney MJ, Tan MH. SRSF9 selectively represses ADAR2-mediated editing of brain-specific sites in primates. Nucleic Acids Res. 2018 Jul 10. doi: 10.1093/nar/gky615. [Epub ahead of print] PubMed PMID: 29992293.

3: Zhang Q, Yang B, Li F, Liu M, Lin S, Wang J, Xue Y, Zhu H, Sun W, Hu Z, Zhang Y. Mycophenolic Acid Derivatives with Immunosuppressive Activity from the Coral-Derived Fungus Penicillium bialowiezense. Mar Drugs. 2018 Jul 7;16(7). pii: E230. doi: 10.3390/md16070230. PubMed PMID: 29986508.

4: Kopiec G, Starzec K, Kochana J, Kinnunen-Skidmore TP, Schuhmann W, Campbell WH, Ruff A, Plumeré N. Bioelectrocatalytic and electrochemical cascade for phosphate sensing with up to 6 electrons per analyte molecule. Biosens Bioelectron. 2018 Jun 25;117:501-507. doi: 10.1016/j.bios.2018.06.047. [Epub ahead of print] PubMed PMID: 29982120.

5: Md Dom ZI, Coller JK, Carroll RP, Tuke J, McWhinney BC, Somogyi AA, Sallustio BC. Mycophenolic Acid Concentrations in Peripheral Blood Mononuclear Cells are Associated with the Incidence of Rejection in Renal Transplant Recipients. Br J Clin Pharmacol. 2018 Jul 2. doi: 10.1111/bcp.13704. [Epub ahead of print] PubMed PMID: 29974488.

6: Vogel P, Moschref M, Li Q, Merkle T, Selvasaravanan KD, Li JB, Stafforst T. Efficient and precise editing of endogenous transcripts with SNAP-tagged ADARs. Nat Methods. 2018 Jul;15(7):535-538. doi: 10.1038/s41592-018-0017-z. Epub 2018 Jul 2. PubMed PMID: 29967493.

7: Liu F, Xu L, Sheng C, Qiu X, Zhang M, Jiao Z. Optimization and application of an HPLC method for quantification of Inosine-5'-monophosphate dehydrogenase activity as a pharmacodynamic biomarker of mycophenolic acid in Chinese renal transplant patients. Clin Chim Acta. 2018 Jun 28. pii: S0009-8981(18)30328-0. doi: 10.1016/j.cca.2018.06.042. [Epub ahead of print] PubMed PMID: 29964005.

8: Mao HG, Cao HY, Liu HH, Dong XY, Xu NY, Yin ZZ. Association of ADSL gene polymorphisms with meat quality and carcass traits in domestic pigeons (Columba livia). Br Poult Sci. 2018 Jul 2. doi: 10.1080/00071668.2018.1493188. [Epub ahead of print] PubMed PMID: 29963908.

9: Zhao Y, Yang Y, Dai J, Xing D, Dong Y. IMPDH2 is highly expressed in breast cancer and predicts unfavourable prognosis. Biomarkers. 2018 Jul 2:1-9. doi: 10.1080/1354750X.2018.1496360. [Epub ahead of print] PubMed PMID: 29962242.

10: Cheng T, Jiao Z, Liu X, Zhang H. Selective, fast and semi-automatic enrichment of nucleosides by using a phenylboronic acid modified hybrid material composed of graphene oxide and melamine sponge. Mikrochim Acta. 2018 Jun 30;185(7):348. doi: 10.1007/s00604-018-2878-3. PubMed PMID: 29961121.

11: Galipon J, Ishii R, Ishiguro S, Suzuki Y, Kondo S, Okada-Hatakeyama M, Tomita M, Ui-Tei K. High-Quality Overlapping Paired-End Reads for the Detection of A-to-I Editing on Small RNA. Methods Mol Biol. 2018;1823:167-183. doi: 10.1007/978-1-4939-8624-8_13. PubMed PMID: 29959681.

12: Morena F, Argentati C, Bazzucchi M, Emiliani C, Martino S. Above the Epitranscriptome: RNA Modifications and Stem Cell Identity. Genes (Basel). 2018 Jun 28;9(7). pii: E329. doi: 10.3390/genes9070329. Review. PubMed PMID: 29958477.

13: Špačková N, Réblová K. Role of Inosine⁻Uracil Base Pairs in the Canonical RNA Duplexes. Genes (Basel). 2018 Jun 28;9(7). pii: E324. doi: 10.3390/genes9070324. PubMed PMID: 29958383.

14: Peng L, Zhang H, Su Y, Shen Q, Du C, Xie H, Li H, Yan J, Shen Z, Jiang W, Xia Y, Xu X, Tang W. Lipopolysaccharide enhances ADAR2 which drives Hirschsprung's disease by impairing miR-142-3p biogenesis. J Cell Mol Med. 2018 Jun 29. doi: 10.1111/jcmm.13652. [Epub ahead of print] PubMed PMID: 29956457.

15: Ishiguro S, Galipon J, Ishii R, Suzuki Y, Kondo S, Okada-Hatakeyama M, Tomita M, Ui-Tei K. Base-pairing probability in the microRNA stem region affects the binding and editing specificity of human A-to-I editing enzymes ADAR1-p110 and ADAR2. RNA Biol. 2018 Jun 27. doi: 10.1080/15476286.2018.1486658. [Epub ahead of print] PubMed PMID: 29950133.

16: Keppeke GD, Chang CC, Peng M, Chen LY, Lin WC, Pai LM, Andrade LEC, Sung LY, Liu JL. IMP/GTP balance modulates cytoophidium assembly and IMPDH activity. Cell Div. 2018 Jun 15;13:5. doi: 10.1186/s13008-018-0038-0. eCollection 2018. PubMed PMID: 29946345; PubMed Central PMCID: PMC6004095.

17: Liu D, Mao Z, Guo J, Wei L, Ma H, Tang Y, Chen T, Wang Z, Zhao X. Construction, Model-Based Analysis, and Characterization of a Promoter Library for Fine-Tuned Gene Expression in Bacillus subtilis. ACS Synth Biol. 2018 Jul 10. doi: 10.1021/acssynbio.8b00115. [Epub ahead of print] PubMed PMID: 29944832.

18: Nepal M, Ma C, Xie G, Jia W, Fei P. Fanconi Anemia complementation group C protein in metabolic disorders. Aging (Albany NY). 2018 Jun 21;10(6):1506-1522. doi: 10.18632/aging.101487. PubMed PMID: 29930218.

19: Shigeyasu K, Okugawa Y, Toden S, Miyoshi J, Toiyama Y, Nagasaka T, Takahashi N, Kusunoki M, Takayama T, Yamada Y, Fujiwara T, Chen L, Goel A. AZIN1 RNA editing confers cancer stemness and enhances oncogenic potential in colorectal cancer. JCI Insight. 2018 Jun 21;3(12). pii: 99976. doi: 10.1172/jci.insight.99976. [Epub ahead of print] PubMed PMID: 29925690.

20: Huang N, Ling H, Liu F, Su Y, Su W, Mao H, Zhang X, Wang L, Chen R, Que Y. Identification and evaluation of PCR reference genes for host and pathogen in sugarcane-Sporisorium scitamineum interaction system. BMC Genomics. 2018 Jun 19;19(1):479. doi: 10.1186/s12864-018-4854-z. PubMed PMID: 29914370; PubMed Central PMCID: PMC6006842.

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Inosine featured