WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H597993
CAS#: 132116-62-2
Description: Peptide 78 identical to peptide 74 except that serine replaces cysteine; does not inhibit 72-kDa type IV collagenase.
Hodoodo Cat#: H597993
Name: Peptide 78
CAS#: 132116-62-2
Chemical Formula: C60H106N22O20S
Exact Mass: 1,486.77
Molecular Weight: 1,487.700
Elemental Analysis: C, 48.44; H, 7.18; N, 20.71; O, 21.51; S, 2.16
This product is not in stock, which may be available by custom synthesis.
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Synonym: Peptide 78; Peptide-78; Peptide78; Thr-met-arg-lys-pro-arg-ser-gly-asn-pro-asp-val-ala-asn;
IUPAC/Chemical Name: (S)-3-((S)-1-(L-threonyl-L-methionyl-L-arginyl-L-lysyl-L-arginyl-L-serylglycyl-L-asparaginyl)pyrrolidine-2-carboxamido)-4-(((S)-1-(((S)-1-(((S)-3-amino-1-carboxy-3-oxopropyl)(propyl)amino)-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)amino)-4-oxobutanoic acid
InChi Key: OPKCDFWAZKOPFX-OMBAYSRHSA-N
InChi Code: InChI=1S/C60H106N22O20S/c1-7-21-81(40(58(101)102)26-42(63)86)56(99)30(4)72-55(98)46(29(2)3)80-52(95)36(25-44(88)89)78-53(96)39-16-12-22-82(39)57(100)37(24-41(62)85)73-43(87)27-71-47(90)38(28-83)79-50(93)34(15-11-20-70-60(67)68)75-48(91)32(13-8-9-18-61)74-49(92)33(14-10-19-69-59(65)66)76-51(94)35(17-23-103-6)77-54(97)45(64)31(5)84/h29-40,45-46,83-84H,7-28,61,64H2,1-6H3,(H2,62,85)(H2,63,86)(H,71,90)(H,72,98)(H,73,87)(H,74,92)(H,75,91)(H,76,94)(H,77,97)(H,78,96)(H,79,93)(H,80,95)(H,88,89)(H,101,102)(H4,65,66,69)(H4,67,68,70)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,45-,46-/m0/s1
SMILES Code: O=C(N)C[C@@H](C(O)=O)N(CCC)C([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H]1N(C([C@H](CC(N)=O)NC(CNC([C@H](CO)NC([C@H](CCCNC(N)=N)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@H](CCSC)NC([C@H]([C@H](O)C)N)=O)=O)=O)=O)=O)=O)=O)=O)CCC1)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,487.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Yang T, Wang S, Zheng Q, Wang L, Li Q, Wei M, Du Z, Fan Y. Increased plasma levels of epithelial neutrophil-activating peptide 78/CXCL5 during the remission of Neuromyelitis optica. BMC Neurol. 2016 Jul 11;16:96. doi: 10.1186/s12883-016-0622-3. PubMed PMID: 27401736; PubMed Central PMCID: PMC4940958.
2: Wang H, Zhao J, Xue G, Wang J, Wu J, Wang D, Dong L. Regulatory effect of cytokine-induced neutrophil chemoattractant, epithelial neutrophil-activating peptide 78 and pyrrolidine dithiocarbamate on pulmonary neutrophil aggregation mediated by nuclear factor-κB in lipopolysaccharide-induced acute respiratory distress syndrome mice. Exp Ther Med. 2016 Sep;12(3):1785-1794. Epub 2016 Jul 13. PubMed PMID: 27602092; PubMed Central PMCID: PMC4998193.
3: Zats GM, Kovaliov M, Albeck A, Shatzmiller S. Antimicrobial benzodiazepine-based short cationic peptidomimetics. J Pept Sci. 2015 Jun;21(6):512-9. doi: 10.1002/psc.2771. Epub 2015 Mar 25. PubMed PMID: 25807936.
4: Buer BC, Chugh J, Al-Hashimi HM, Marsh EN. Using fluorine nuclear magnetic resonance to probe the interaction of membrane-active peptides with the lipid bilayer. Biochemistry. 2010 Jul 13;49(27):5760-5. doi: 10.1021/bi100605e. PubMed PMID: 20527804.
5: Melchiori A, Albini A, Ray JM, Stetler-Stevenson WG. Inhibition of tumor cell invasion by a highly conserved peptide sequence from the matrix metalloproteinase enzyme prosegment. Cancer Res. 1992 Apr 15;52(8):2353-6. PubMed PMID: 1313744.
6: Lim JB, Chung HW. Serum ENA78/CXCL5, SDF-1/CXCL12, and their combinations as potential biomarkers for prediction of the presence and distant metastasis of primary gastric cancer. Cytokine. 2015 May;73(1):16-22. doi: 10.1016/j.cyto.2015.01.010. Epub 2015 Feb 14. PubMed PMID: 25689618.
7: Liu L, Chowdhury S, Fang X, Liu JL, Srikant CB. Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells. FEBS Lett. 2014 May 29;588(11):2016-24. doi: 10.1016/j.febslet.2014.04.030. Epub 2014 May 4. PubMed PMID: 24801175.
8: Li Z, Wang Z, Zhang C, Chen J, Su Y, Huang J, Yi Z, Yuan C, Hong W, Wang Y, Wu Z, Hu Y, Cao L, Peng D, Guan Y, Zou Y, Yu S, Cui D, Fang Y. Reduced ENA78 levels as novel biomarker for major depressive disorder and venlafaxine efficiency: Result from a prospective longitudinal study. Psychoneuroendocrinology. 2017 Jul;81:113-121. doi: 10.1016/j.psyneuen.2017.03.015. Epub 2017 Mar 18. PubMed PMID: 28441588.