WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H598029
CAS#: 133136-47-7
Description: Bam 1745 is a significant component of adrenomedullary secretory vesicles; fragment of chromogranin B Gln(580)-Tyr(593).
Hodoodo Cat#: H598029
Name: Bam 1745
CAS#: 133136-47-7
Chemical Formula: C79H116N20O25
Exact Mass: 1,744.84
Molecular Weight: 1,745.910
Elemental Analysis: C, 54.35; H, 6.70; N, 16.05; O, 22.91
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Synonym: Bam 1745; Bam-1745; Bam1745; Pyroglutamyl peptide bam-1745;
IUPAC/Chemical Name: (2S,5S,8S,11S,14S,17S,20S,23S,26S,29S,32S,35S)-5-((1H-imidazol-4-yl)methyl)-14-(3-amino-3-oxopropyl)-23-(2-carboxyethyl)-17-(carboxymethyl)-32-(3-guanidinopropyl)-2-(4-hydroxybenzyl)-35-((S)-3-(4-hydroxyphenyl)-2-((S)-5-oxopyrrolidine-2-carboxamido)propanamido)-8,11,20-triisobutyl-29-isopropyl-26-methyl-4,7,10,13,16,19,22,25,28,31,34-undecaoxo-3,6,9,12,15,18,21,24,27,30,33-undecaazaheptatriacontanedioic acid
InChi Key: JHRLXGDAMQJZGK-ARICVWHCSA-N
InChi Code: InChI=1S/C79H116N20O25/c1-37(2)27-51(70(115)93-53(29-39(5)6)71(116)95-55(32-44-35-83-36-85-44)74(119)98-58(78(123)124)31-43-14-18-46(101)19-15-43)91-67(112)49(20-23-59(80)102)90-76(121)57(34-63(108)109)96-72(117)52(28-38(3)4)92-68(113)50(22-25-61(104)105)88-65(110)41(9)86-77(122)64(40(7)8)99-69(114)47(11-10-26-84-79(81)82)89-75(120)56(33-62(106)107)97-73(118)54(30-42-12-16-45(100)17-13-42)94-66(111)48-21-24-60(103)87-48/h12-19,35-41,47-58,64,100-101H,10-11,20-34H2,1-9H3,(H2,80,102)(H,83,85)(H,86,122)(H,87,103)(H,88,110)(H,89,120)(H,90,121)(H,91,112)(H,92,113)(H,93,115)(H,94,111)(H,95,116)(H,96,117)(H,97,118)(H,98,119)(H,99,114)(H,104,105)(H,106,107)(H,108,109)(H,123,124)(H4,81,82,84)/t41-,47-,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,64-/m0/s1
SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](CC2=CNC=N2)NC([C@H](CC(C)C)NC([C@H](CC(C)C)NC([C@H](CCC(N)=O)NC([C@H](CC(O)=O)NC([C@H](CC(C)C)NC([C@H](CCC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CCCNC(N)=N)NC([C@H](CC(O)=O)NC([C@H](CC3=CC=C(O)C=C3)NC([C@H](CC4)NC4=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,745.91 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Flanagan T, Taylor L, Poulter L, Viveros OH, Diliberto EJ Jr. A novel 1745-dalton pyroglutamyl peptide derived from chromogranin B is in the bovine adrenomedullary chromaffin vesicle. Cell Mol Neurobiol. 1990 Dec;10(4):507-23. PubMed PMID: 1982622.
2: Dillen L, Boel S, De Potter WP, Claeys M. Mass spectrometric characterization of bovine chromaffin granule peptides related to chromogranin B. Biochim Biophys Acta. 1992 Mar 27;1120(1):105-12. PubMed PMID: 1554736.