Diacetylsplenopentin HCl

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Hodoodo CAT#: H598054

CAS#: 122402-38-4

Description: Diacetylsplenopentin HCl is a synthetic immunomodulator that affects the proliferation and differentiation of bone marrow stem cells without stimulating pathological immune responses beyond the balance of the immune system. This effect is specifically studied on leukocytes.


Chemical Structure

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Diacetylsplenopentin HCl
CAS# 122402-38-4

Theoretical Analysis

Hodoodo Cat#: H598054
Name: Diacetylsplenopentin HCl
CAS#: 122402-38-4
Chemical Formula: C35H56ClN9O11
Exact Mass: 813.38
Molecular Weight: 814.330
Elemental Analysis: C, 51.62; H, 6.93; Cl, 4.35; N, 15.48; O, 21.61

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Diacetylsplenopentin hydrochloride; Diacetylsplenopentin HCl;

IUPAC/Chemical Name: (6S,9S,12S,15S,18S)-6-acetamido-9-(4-acetamidobutyl)-1-amino-12-(2-carboxyethyl)-18-(4-hydroxybenzyl)-1-imino-15-isopropyl-7,10,13,16-tetraoxo-2,8,11,14,17-pentaazanonadecan-19-oic acid hydrochloride

InChi Key: MAZFTYVMQDNCCO-WRRQFKQISA-N

InChi Code: InChI=1S/C35H55N9O11.ClH/c1-19(2)29(33(53)43-27(34(54)55)18-22-10-12-23(47)13-11-22)44-32(52)26(14-15-28(48)49)42-31(51)25(8-5-6-16-38-20(3)45)41-30(50)24(40-21(4)46)9-7-17-39-35(36)37;/h10-13,19,24-27,29,47H,5-9,14-18H2,1-4H3,(H,38,45)(H,40,46)(H,41,50)(H,42,51)(H,43,53)(H,44,52)(H,48,49)(H,54,55)(H4,36,37,39);1H/t24-,25-,26-,27-,29-;/m0./s1

SMILES Code: OC1=CC=C(C=C1)C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CCCCNC(C)=O)NC([C@H](CCCNC(N)=N)NC(C)=O)=O)=O)=O)=O.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 814.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Liebermann HT, Thalmann G, Bartels T, Nöckler A. Experiments on an early protection against foot-and-mouth disease virus. Acta Virol. 1993 Apr-Jun;37(2-3):181-3. PubMed PMID: 8105663.

2: Bräuer R, Thoss K, Henzgen S, Waldmann G. Effects of the immunomodulator diacetyl-splenopentin on antigen-induced arthritis in rabbits. Agents Actions. 1992 Jan;35(1-2):96-103. PubMed PMID: 1387284.

3: Simon HU, Lauterbach H, Börner A, Wachtel S. Diacetyl-splenopentin (BCH 069) did not affect the concentrations of various hormones in men. Exp Clin Endocrinol. 1990 Dec;96(3):314-6. PubMed PMID: 2083571.

4: Simon HU, Metzner G, Vogt WE, Piesch C, Forner K, Schlenvoigt G, Storz H, Haroske D, Jäger L. Clinical, biochemical and immunological effectiveness of diacetyl-splenopentin (BCH 069) in hay fever. Allergol Immunopathol (Madr). 1990 May-Jun;18(3):155-60. PubMed PMID: 2251976.

5: Simon HU, Kraul H, Schäfer R, Kilian U, Hoffmann A. Lack of effect of diacetyl-splenopentin (Berlopentin) on the pharmacokinetics of caffeine. Pharmazie. 1992 Jan;47(1):49-50. PubMed PMID: 1608985.

6: Simon HU, Reipert B, Haroske D, Forner K, Storz H. [Age-dependent sensitivity of human lymphocytes to the immunomodulating effect of bovine and human diacetyl splenopentin]. Allerg Immunol (Leipz). 1990;36(4):351-8. German. PubMed PMID: 2151503.

7: Baumgart J, Zippel D. Age-dependent experimental tumor dissemination of murine melanoma B16. Arch Immunol Ther Exp (Warsz). 1991;39(5-6):489-94. PubMed PMID: 1841547.

8: Simon HU, Forner K, Büttner A, Haroske D, Vogt KH. [The lymphocyte transformation test using mononuclear cells of elderly humans as a suitable in vitro method for testing of structure activity relationships of splenin peptides]. Pharmazie. 1990 Dec;45(12):917-9. German. PubMed PMID: 2100799.

9: Simon HU, Metzner G, Keil E, Forner K, Vogt WE, Jäger L. Phase-I study of diacetyl-splenopentin (BCH 069). Allerg Immunol (Leipz). 1990;36(4):245-51. PubMed PMID: 1982983.