WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H598059
CAS#: 108890-90-0
Description: K-13 is an ACE inhibitor produced by Micromonospora halophytics subsp. exilisia K-13.
Hodoodo Cat#: H598059
Name: K-13
CAS#: 108890-90-0
Chemical Formula: C29H29N3O8
Exact Mass: 547.20
Molecular Weight: 547.560
Elemental Analysis: C, 63.61; H, 5.34; N, 7.67; O, 23.37
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: K-13 (Ace inhib); K-13; K 13; K13;
IUPAC/Chemical Name: (E)-2-(((S)-2-((Z)-2-acetamido-3-(4-hydroxyphenyl)acrylamido)-3-(4-hydroxyphenyl)propyl)amino)-3-(3,4-dihydroxyphenyl)acrylic acid
InChi Key: HYTQWQKWYAFIQQ-BHXOFZDCSA-N
InChi Code: InChI=1S/C29H29N3O8/c1-17(33)31-24(13-19-4-9-23(35)10-5-19)28(38)32-21(12-18-2-7-22(34)8-3-18)16-30-25(29(39)40)14-20-6-11-26(36)27(37)15-20/h2-11,13-15,21,30,34-37H,12,16H2,1H3,(H,31,33)(H,32,38)(H,39,40)/b24-13-,25-14+/t21-/m0/s1
SMILES Code: CC(N/C(C(N[C@H](CN/C(C(O)=O)=C/c1cc(O)c(O)cc1)Cc2ccc(O)cc2)=O)=C\c3ccc(O)cc3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 547.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Ozguner F, Armagan A, Koyu A, Caliskan S, Koylu H. A novel antioxidant agent caffeic acid phenethyl ester prevents shock wave-induced renal tubular oxidative stress. Urol Res. 2005 Jun;33(3):239-43. Epub 2005 May 5. PubMed PMID: 15877224.
2: Ozguner F, Bardak Y, Comlekci S. Protective effects of melatonin and caffeic acid phenethyl ester against retinal oxidative stress in long-term use of mobile phone: a comparative study. Mol Cell Biochem. 2006 Jan;282(1-2):83-8. PubMed PMID: 16317515.
3: Ozguner F, Oktem F, Armagan A, Yilmaz R, Koyu A, Demirel R, Vural H, Uz E. Comparative analysis of the protective effects of melatonin and caffeic acid phenethyl ester (CAPE) on mobile phone-induced renal impairment in rat. Mol Cell Biochem. 2005 Aug;276(1-2):31-7. PubMed PMID: 16132682.
4: Ozguner F, Oktem F, Ayata A, Koyu A, Yilmaz HR. A novel antioxidant agent caffeic acid phenethyl ester prevents long-term mobile phone exposure-induced renal impairment in rat. Prognostic value of malondialdehyde, N-acetyl-beta-D-glucosaminidase and nitric oxide determination. Mol Cell Biochem. 2005 Sep;277(1-2):73-80. PubMed PMID: 16132717.
5: Gao X, Deeb D, Media J, Divine G, Jiang H, Chapman RA, Gautam SC. Immunomodulatory activity of resveratrol: discrepant in vitro and in vivo immunological effects. Biochem Pharmacol. 2003 Dec 15;66(12):2427-35. PubMed PMID: 14637200.
6: Oktem F, Ozguner F, Sulak O, Olgar S, Akturk O, Yilmaz HR, Altuntas I. Lithium-induced renal toxicity in rats: protection by a novel antioxidant caffeic acid phenethyl ester. Mol Cell Biochem. 2005 Sep;277(1-2):109-15. PubMed PMID: 16132721.