WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H563363
CAS#: 192718-06-2
Description: C527 is a inhibitor of USP1 target ID1 degradation in leukemic cells.
Hodoodo Cat#: H563363
Name: C527
CAS#: 192718-06-2
Chemical Formula: C17H8FNO3
Exact Mass: 293.05
Molecular Weight: 293.250
Elemental Analysis: C, 69.63; H, 2.75; F, 6.48; N, 4.78; O, 16.37
Synonym: C527; C-527; C 527;
IUPAC/Chemical Name: 2-(4-Fluorophenyl)-naphth[2,3-d]oxazole-4,9-dione
InChi Key: ULJDFEYQOPCCPM-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H8FNO3/c18-10-7-5-9(6-8-10)17-19-13-14(20)11-3-1-2-4-12(11)15(21)16(13)22-17/h1-8H
SMILES Code: O=C(C1=C2OC(C3=CC=C(F)C=C3)=N1)C4=C(C=CC=C4)C2=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 293.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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12: Vogalis F, Lang RJ, Bywater RA, Taylor GS. Voltage-gated ionic currents in smooth muscle cells of guinea pig proximal colon. Am J Physiol. 1993 Mar;264(3 Pt 1):C527-36. PubMed PMID: 8384782.
13: Shetty M, Loeb JN, Ismail-Beigi F. Enhancement of glucose transport in response to inhibition of oxidative metabolism: pre- and posttranslational mechanisms. Am J Physiol. 1992 Feb;262(2 Pt 1):C527-32. PubMed PMID: 1539639.
14: Restrepo D, Cronise BL, Snyder RB, Spinelli LJ, Knauf PA. Kinetics of DIDS inhibition of HL-60 cell anion exchange rules out ping-pong model with slippage. Am J Physiol. 1991 Mar;260(3 Pt 1):C535-44. PubMed PMID: 1848401.
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16: Ahn J, Chang EB, Field M. Phorbol ester inhibition of Na-H exchange in rabbit proximal colon. Am J Physiol. 1985 Nov;249(5 Pt 1):C527-30. PubMed PMID: 3864381.
17: Pace CS, Goldsmith KT. Action of a phorbol ester on B-cells: potentiation of stimulant-induced electrical activity. Am J Physiol. 1985 May;248(5 Pt 1):C527-34. PubMed PMID: 3158214.