Soblidotin

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H598092

CAS#: 149606-27-9

Description: Soblidotin is a dolastatin 10 derivative.


Chemical Structure

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Soblidotin
CAS# 149606-27-9

Theoretical Analysis

Hodoodo Cat#: H598092
Name: Soblidotin
CAS#: 149606-27-9
Chemical Formula: C39H67N5O6
Exact Mass: 701.51
Molecular Weight: 701.990
Elemental Analysis: C, 66.73; H, 9.62; N, 9.98; O, 13.67

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Soblidotin; TZT-1027; TZT 1027; TZT1027;

IUPAC/Chemical Name: (S)-N-(dimethyl-L-valyl)-2-(((3R,4S,5S)-3-methoxy-1-((S)-2-((1R,2R)-1-methoxy-2-methyl-3-oxo-3-(phenethylamino)propyl)pyrrolidin-1-yl)-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methylbutanamide

InChi Key: WGTOWXLPARJQGY-ZBFGKEHZSA-N

InChi Code: InChI=1S/C39H67N5O6/c1-13-27(6)35(43(10)34(26(4)5)39(48)41-38(47)33(25(2)3)42(8)9)31(49-11)24-32(45)44-23-17-20-30(44)36(50-12)28(7)37(46)40-22-21-29-18-15-14-16-19-29/h14-16,18-19,25-28,30-31,33-36H,13,17,20-24H2,1-12H3,(H,40,46)(H,41,47,48)/t27-,28+,30-,31+,33-,34-,35-,36+/m0/s1

SMILES Code: CC(C)[C@@H](C(NC([C@H](C(C)C)N(C)C)=O)=O)N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(NCCC2=CC=CC=C2)=O)CCC1)=O)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 701.99 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Watanabe J, Minami M, Kobayashi M. Antitumor activity of TZT-1027 (Soblidotin). Anticancer Res. 2006 May-Jun;26(3A):1973-81. PubMed PMID: 16827132.

2: Natsume T, Watanabe J, Horiuchi T, Kobayashi M. Combination effect of TZT-1027 (Soblidotin) with other anticancer drugs. Anticancer Res. 2006 Mar-Apr;26(2A):1145-51. PubMed PMID: 16619516.

3: Watanabe J, Natsume T, Kobayashi M. Antivascular effects of TZT-1027 (Soblidotin) on murine Colon26 adenocarcinoma. Cancer Sci. 2006 Dec;97(12):1410-6. Epub 2006 Sep 25. PubMed PMID: 16999818.

4: Watanabe J, Natsume T, Kobayashi M. Comparison of the antivascular and cytotoxic activities of TZT-1027 (Soblidotin) with those of other anticancer agents. Anticancer Drugs. 2007 Sep;18(8):905-11. PubMed PMID: 17667596.

5: Natsume T, Watanabe J, Ogawa K, Yasumura K, Kobayashi M. Tumor-specific antivascular effect of TZT-1027 (Soblidotin) elucidated by magnetic resonance imaging and confocal laser scanning microscopy. Cancer Sci. 2007 Apr;98(4):598-604. Epub 2007 Jan 31. PubMed PMID: 17284247.

6: Watanabe J, Endo Y, Shimada N, Natsume T, Sasaki T, Kobayashi M. Antiangiogenic activity of TZT-1027 (soblidotin) on chick chorioallantoic membrane and human umbilical vein endothelial cells. In Vivo. 2007 Mar-Apr;21(2):297-304. PubMed PMID: 17436580.

7: Natsume T, Watanabe J, Koh Y, Fujio N, Ohe Y, Horiuchi T, Saijo N, Nishio K, Kobayashi M. Antitumor activity of TZT-1027 (Soblidotin) against vascular endothelial growth factor-secreting human lung cancer in vivo. Cancer Sci. 2003 Sep;94(9):826-33. PubMed PMID: 12967483.

8: Watanabe J, Natsume T, Kobayashi M. The inhibitory effect of docetaxel and p38 MAPK inhibitor on TZT-1027 (Soblidotin)-induced antivascular activity. Anticancer Res. 2007 Nov-Dec;27(6B):3909-18. PubMed PMID: 18225550.

9: Shimoyama T, Hamano T, Natsume T, Koizumi F, Kiura K, Tanimoto M, Nishio K. Reference profiling of the genomic response induced by an antimicrotubule agent, TZT-1027 (Soblidotin), in vitro. Pharmacogenomics J. 2006 Nov-Dec;6(6):388-96. Epub 2006 Mar 21. PubMed PMID: 16550209.

10: Yan Q, Wang Y, Zhang W, Li Y. Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents. Mar Drugs. 2016 Apr 28;14(5). pii: E85. doi: 10.3390/md14050085. PubMed PMID: 27136567; PubMed Central PMCID: PMC4882559.

11: Doronina SO, Toki BE, Torgov MY, Mendelsohn BA, Cerveny CG, Chace DF, DeBlanc RL, Gearing RP, Bovee TD, Siegall CB, Francisco JA, Wahl AF, Meyer DL, Senter PD. Development of potent monoclonal antibody auristatin conjugates for cancer therapy. Nat Biotechnol. 2003 Jul;21(7):778-84. Epub 2003 Jun 1. PubMed PMID: 12778055.

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13: Cormier A, Marchand M, Ravelli RB, Knossow M, Gigant B. Structural insight into the inhibition of tubulin by vinca domain peptide ligands. EMBO Rep. 2008 Nov;9(11):1101-6. doi: 10.1038/embor.2008.171. Epub 2008 Sep 12. PubMed PMID: 18787557; PubMed Central PMCID: PMC2581847.

14: Horti J, Juhasz E, Monostori Z, Maeda K, Eckhardt S, Bodrogi I. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative, for the treatment of patients with non-small cell lung cancer. Cancer Chemother Pharmacol. 2008 Jun;62(1):173-80. doi: 10.1007/s00280-007-0665-7. Epub 2008 Jan 23. PubMed PMID: 18214483.

15: Cai YC, Zou Y, Xian LJ. [Advances in the study of the anti-tumor activity of small molecule vascular disrupting agents]. Yao Xue Xue Bao. 2010 Mar;45(3):283-8. Review. Chinese. PubMed PMID: 21351502.

16: Tamura K, Nakagawa K, Kurata T, Satoh T, Nogami T, Takeda K, Mitsuoka S, Yoshimura N, Kudoh S, Negoro S, Fukuoka M. Phase I study of TZT-1027, a novel synthetic dolastatin 10 derivative and inhibitor of tubulin polymerization, which was administered to patients with advanced solid tumors on days 1 and 8 in 3-week courses. Cancer Chemother Pharmacol. 2007 Jul;60(2):285-93. Epub 2006 Nov 30. PubMed PMID: 17136542.

17: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 May;29(4):303-11. PubMed PMID: 17609744.

18: Bayés M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2004 Jan-Feb;26(1):53-84. Review. PubMed PMID: 14988742.

19: Watanabe K, Tanimura S, Uchiyama A, Sakamoto T, Kawabata T, Ozaki K, Kohno M. Blockade of the extracellular signal-regulated kinase pathway enhances the therapeutic efficacy of microtubule-destabilizing agents in human tumor xenograft models. Clin Cancer Res. 2010 Feb 15;16(4):1170-8. doi: 10.1158/1078-0432.CCR-09-2482. Epub 2010 Feb 9. PubMed PMID: 20145173.

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