WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H592375
CAS#: 16234-96-1
Description: Aklavinone is a biochemical.
Hodoodo Cat#: H592375
Name: Aklavinone
CAS#: 16234-96-1
Chemical Formula: C22H20O8
Exact Mass: 412.12
Molecular Weight: 412.390
Elemental Analysis: C, 64.08; H, 4.89; O, 31.04
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Synonym: Aklavinone; NSC 114780; NSC-114780; NSC114780
IUPAC/Chemical Name: 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,4,5,7-tetrahydroxy-6,11-dioxo-, methyl ester, (1R,2R,4S)- (8CI)
InChi Key: RACGRCLGVYXIAO-YOKWENHESA-N
InChi Code: InChI=1S/C22H20O8/c1-3-22(29)8-13(24)15-10(17(22)21(28)30-2)7-11-16(20(15)27)19(26)14-9(18(11)25)5-4-6-12(14)23/h4-7,13,17,23-24,27,29H,3,8H2,1-2H3/t13-,17-,22+/m0/s1
SMILES Code: O=C([C@H]1[C@@](O)(CC)C[C@H](O)C(C(O)=C2C(C3=C4C=CC=C3O)=O)=C1C=C2C4=O)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 412.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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4: Lindqvist Y, Koskiniemi H, Jansson A, Sandalova T, Schnell R, Liu Z, Mäntsälä P, Niemi J, Schneider G. Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis. J Mol Biol. 2009 Nov 6;393(4):966-77. doi: 10.1016/j.jmb.2009.09.003. Epub 2009 Sep 8. PubMed PMID: 19744497.
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10: Chung JY, Fujii I, Harada S, Sankawa U, Ebizuka Y. Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. J Bacteriol. 2002 Nov;184(22):6115-22. PubMed PMID: 12399480; PubMed Central PMCID: PMC151955.
11: Räty K, Kantola J, Hautala A, Hakala J, Ylihonko K, Mäntsälä P. Cloning and characterization of Streptomyces galilaeus aclacinomycins polyketide synthase (PKS) cluster. Gene. 2002 Jun 26;293(1-2):115-22. PubMed PMID: 12137949.
12: Wang Y, Niemi J, Mäntsälä P. Modification of aklavinone and aclacinomycins in vitro and in vivo by rhodomycin biosynthesis gene products. FEMS Microbiol Lett. 2002 Feb 19;208(1):117-22. PubMed PMID: 11934504.
13: Räty K, Kunnari T, Hakala J, Mäntsälä P, Ylihonko K. A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin. Mol Gen Genet. 2000 Sep;264(1-2):164-72. PubMed PMID: 11016846.
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19: Kim HS, Kim YH, Yoo OJ, Lee JJ. Aclacinomycin X, a novel anthracycline antibiotic produced by Streptomyces galilaeus ATCC 31133. Biosci Biotechnol Biochem. 1996 May;60(5):906-8. PubMed PMID: 8704322.
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