K-41

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H598150

CAS#: 53026-37-2

Description: K 41 is a polycyclic polyether antibiotic isolated from Streptomyces hygroscopicus.

Chemical Structure

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K-41
CAS# 53026-37-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H598150
Name: K-41
CAS#: 53026-37-2
Chemical Formula: C48H82O18
Exact Mass: 946.55
Molecular Weight: 947.160
Elemental Analysis: C, 60.87; H, 8.73; O, 30.40

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: K 41; K41; K-41; Antibiotic K-41A; Antibiotic A 32887; 37454 RP; Antibiotic 37454 RP;

IUPAC/Chemical Name: 2-hydroxy-2-((2R,3R,4R,5R,6R)-2-hydroxy-6-(((2S,5R,7S,9R,10R)-2-(5'-(6-hydroxy-4-((5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)octahydro-[2,2'-bifuran]-5-yl)-3,9-dimethoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-4,5-dimethoxy-3,5-dimethyltetrahydro-2H-pyran-2-yl)acetic acid

InChi Key: QFHLVPYVNFSTBE-YUJCGUFPSA-N

InChi Code: InChI=1S/C48H82O18/c1-23-38(62-37-20-18-30(54-10)28(6)59-37)25(3)46(9,52)65-39(23)33-16-15-31(60-33)32-17-19-35(61-32)45(8)42(57-13)27(5)48(66-45)24(2)34(55-11)21-29(63-48)22-36-44(7,58-14)41(56-12)26(4)47(53,64-36)40(49)43(50)51/h23-42,49,52-53H,15-22H2,1-14H3,(H,50,51)/t23?,24-,25?,26-,27?,28?,29+,30?,31?,32?,33?,34-,35?,36-,37?,38?,39?,40?,41-,42?,44-,45+,46?,47-,48-/m1/s1

SMILES Code: O=C(O)C(O)[C@@]1(O)[C@H](C)[C@@H](OC)[C@](C)(OC)[C@@H](C[C@H](C[C@@H](OC)[C@H]2C)O[C@@]32C(C)C(OC)[C@@](C4CCC(C5OC(C6C(C)C(OC7CCC(OC)C(C)O7)C(C)C(C)(O)O6)CC5)O4)(C)O3)O1

Appearance: Solid powder

Purity: >70% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 947.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hoshi M, Shimotohno KW, Endo T, Furihata K, Seto H. Microbial and chemical conversion of antibiotic K-41. I. Isolation and identification of conversion product. J Antibiot (Tokyo). 1997 Jul;50(7):631-4. PubMed PMID: 9711256.

2: Otoguro K, Ishiyama A, Ui H, Kobayashi M, Manabe C, Yan G, Takahashi Y, Tanaka H, Yamada H, Omura S. In vitro and in vivo antimalarial activities of the monoglycoside polyether antibiotic, K-41 against drug resistant strains of Plasmodia. J Antibiot (Tokyo). 2002 Sep;55(9):832-4. PubMed PMID: 12458776.

3: Dirlam JP, Bordner J, Cullen WP, Jefferson MT, Presseau-Linabury L. The structure of CP-96,797, a polyether antibiotic related to K-41A and produced by Streptomyces sp. J Antibiot (Tokyo). 1992 Jul;45(7):1187-9. PubMed PMID: 1517165.

4: Hoshi M, Endo T. Microbial and chemical conversion of antibiotic K41. II. Preparation of K41-DA1, -DA2 and -DA3 deamicetosyl derivatives of antibiotic K41. J Antibiot (Tokyo). 2000 Oct;53(10):1154-7. PubMed PMID: 11132961.