WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H461067
CAS#: 104860-61-9
Description: R 50595 is a selective non-competitive antagonist of cisapride.
Hodoodo Cat#: H461067
Name: R 50595
CAS#: 104860-61-9
Chemical Formula: C30H35Cl2F2N3O3
Exact Mass: 593.20
Molecular Weight: 594.520
Elemental Analysis: C, 60.61; H, 5.93; Cl, 11.93; F, 6.39; N, 7.07; O, 8.07
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Synonym: R 50595; R-50595; R50595;
IUPAC/Chemical Name: 4-amino-N-((3S,4R)-1-(4,4-bis(4-fluorophenyl)butyl)-3-methoxypiperidin-4-yl)-5-chloro-2-methoxybenzamide hydrochloride
InChi Key: ODGIHIUVACVQTA-KIIRSEDSSA-N
InChi Code: InChI=1S/C30H34ClF2N3O3.ClH/c1-38-28-17-26(34)25(31)16-24(28)30(37)35-27-13-15-36(18-29(27)39-2)14-3-4-23(19-5-9-21(32)10-6-19)20-7-11-22(33)12-8-20;/h5-12,16-17,23,27,29H,3-4,13-15,18,34H2,1-2H3,(H,35,37);1H/t27-,29+;/m1./s1
SMILES Code: O=C(N[C@H]1[C@@H](OC)CN(CCCC(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3)CC1)C4=CC(Cl)=C(N)C=C4OC.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 594.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Van den Brink HW, Schuurkes JA, Van Nueten JM, Van Rossum JM. R 50 595, a selective non-competitive antagonist of cisapride, BRL 24924 and 5-hydroxytryptamine on the guinea-pig ileum. Eur J Pharmacol. 1990 May 31;181(1-2):119-25. PubMed PMID: 2387319.
2: Meulemans AL, Schuurkes JA. Is the action of cisapride on the guinea-pig ileum mediated via 5-HT4 receptors? Eur J Pharmacol. 1992 Feb 25;212(1):51-9. PubMed PMID: 1555639.