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Benzophenone
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H558460

CAS#: 119-61-9

Description: Benzophenone is a photo initiator in UV-curing applications such as inks, imaging, and clear coatings in the printing industry. Benzophenone prevents ultraviolet (UV) light from damaging scents and colors in products such as perfumes and soaps.

Chemical Structure

Benzophenone

CAS# 119-61-9

Instruction

Theoretical Analysis

Hodoodo Cat#: H558460
Name: Benzophenone
CAS#: 119-61-9
Chemical Formula: C13H10O
Exact Mass: 182.07
Molecular Weight: 182.200
Elemental Analysis: C, 85.69; H, 5.53; O, 8.78

Price and Availability

Size	Price	Availability
1g	USD 210	2 weeks
10g	USD 340	2 weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Benzophenone; Diphenyl ketone; Diphenylketone; Diphenylmethanone;

IUPAC/Chemical Name: Benzophenone

InChi Key: RWCCWEUUXYIKHB-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H10O/c14-13(11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H

SMILES Code: O=C(C1=CC=CC=C1)C2=CC=CC=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 182.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li MD, Huang J, Liu M, Li S, Ma J, Phillips DL. Investigation of the role of protonation of benzophenone and its derivatives in acidic aqueous solutions using time-resolved resonance Raman spectroscopy: how are ketyl radicals formed in aqueous solutions? J Phys Chem B. 2015 Feb 12;119(6):2241-52. doi: 10.1021/jp505954d. Epub 2014 Aug 29. PubMed PMID: 25141023.

2: Mihai DM, Hall S, Deng H, Welch CJ, Kawamura A. Benzophenone and its analogs bind to human glyoxalase 1. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5349-51. doi: 10.1016/j.bmcl.2015.09.036. Epub 2015 Sep 15. PubMed PMID: 26420066; PubMed Central PMCID: PMC4628877.

3: Vela-Soria F, Rodríguez I, Ballesteros O, Zafra-Gómez A, Ballesteros L, Cela R, Navalón A. Simplified matrix solid phase dispersion procedure for the determination of parabens and benzophenone-ultraviolet filters in human placental tissue samples. J Chromatogr A. 2014 Dec 5;1371:39-47. doi: 10.1016/j.chroma.2014.10.063. Epub 2014 Oct 31. PubMed PMID: 25456585.

4: Kim S, Choi K. Occurrences, toxicities, and ecological risks of benzophenone-3, a common component of organic sunscreen products: a mini-review. Environ Int. 2014 Sep;70:143-57. doi: 10.1016/j.envint.2014.05.015. Epub 2014 Jun 14. Review. PubMed PMID: 24934855.

5: Dumont E, Wibowo M, Roca-Sanjuán D, Garavelli M, Assfeld X, Monari A. Resolving the Benzophenone DNA-Photosensitization Mechanism at QM/MM Level. J Phys Chem Lett. 2015 Feb 19;6(4):576-80. doi: 10.1021/jz502562d. Epub 2015 Jan 28. PubMed PMID: 26262469.

6: Han C, Lim YH, Hong YC. Ten-year trends in urinary concentrations of triclosan and benzophenone-3 in the general U.S. population from 2003 to 2012. Environ Pollut. 2016 Jan;208(Pt B):803-10. doi: 10.1016/j.envpol.2015.11.002. Epub 2015 Nov 18. PubMed PMID: 26602792.

7: de Almeida L, Alves KF, Maciel-Rezende CM, Jesus Lde O, Pires FR, Junior CV, Izidoro MA, Júdice WA, dos Santos MH, Marques MJ. Benzophenone derivatives as cysteine protease inhibitors and biological activity against Leishmania(L.) amazonensis amastigotes. Biomed Pharmacother. 2015 Oct;75:93-9. doi: 10.1016/j.biopha.2015.08.030. Epub 2015 Sep 20. PubMed PMID: 26463637.

8: Xiao M, Wei D, Li L, Liu Q, Zhao H, Du Y. Formation pathways of brominated products from benzophenone-4 chlorination in the presence of bromide ions. J Environ Sci (China). 2014 Dec 1;26(12):2387-96. doi: 10.1016/j.jes.2014.03.001. Epub 2014 Oct 16. PubMed PMID: 25499486.

9: Seto Y, Ohtake H, Kato M, Onoue S. Phototoxic Risk Assessments on Benzophenone Derivatives: Photobiochemical Assessments and Dermal Cassette-Dosing Pharmacokinetic Study. J Pharmacol Exp Ther. 2015 Aug;354(2):195-202. doi: 10.1124/jpet.115.223644. Epub 2015 May 27. PubMed PMID: 26016852.

10: Kang HS, Ko A, Kwon JE, Kyung MS, Moon GI, Park JH, Lee HS, Suh JH, Lee JM, Hwang MS, Kim K, Hong JH, Hwang IG. Urinary benzophenone concentrations and their association with demographic factors in a South Korean population. Environ Res. 2016 Aug;149:1-7. doi: 10.1016/j.envres.2016.04.036. Epub 2016 May 5. PubMed PMID: 27155137.

11: Levin PP, Efremkin AF, Khudyakov IV. Kinetics of benzophenone ketyl free radicals recombination in a polymer: reactivity in the polymer cage vs. reactivity in the polymer bulk. Photochem Photobiol Sci. 2015 May;14(5):891-6. doi: 10.1039/c5pp00024f. PubMed PMID: 25712529.

12: Placzek M, Dendorfer M, Przybilla B, Gilbertz KP, Eberlein B. Photosensitizing properties of compounds related to benzophenone. Acta Derm Venereol. 2013 Jan;93(1):30-2. doi: 10.2340/00015555-1421. PubMed PMID: 22983706.

13: Chen DY, Guo XF, Wang H, Zhang HS. The natural degradation of benzophenone at low concentration in aquatic environments. Water Sci Technol. 2015;72(4):503-9. doi: 10.2166/wst.2015.221. PubMed PMID: 26247747.

14: Amar SK, Goyal S, Dubey D, Srivastav AK, Chopra D, Singh J, Shankar J, Chaturvedi RK, Ray RS. Benzophenone 1 induced photogenotoxicity and apoptosis via release of cytochrome c and Smac/DIABLO at environmental UV radiation. Toxicol Lett. 2015 Dec 15;239(3):182-93. doi: 10.1016/j.toxlet.2015.09.024. Epub 2015 Oct 9. PubMed PMID: 26440554.

15: Buck Louis GM, Chen Z, Kim S, Sapra KJ, Bae J, Kannan K. Urinary concentrations of benzophenone-type ultraviolet light filters and semen quality. Fertil Steril. 2015 Oct;104(4):989-996. doi: 10.1016/j.fertnstert.2015.07.1129. Epub 2015 Aug 5. PubMed PMID: 26253817; PubMed Central PMCID: PMC4592813.

16: Kleinschmidt TK, Haraldsson M, Basavarajappa D, Lundeberg E, Thulasingam M, Ekoff M, Fauland A, Lehmann C, Kahnt AS, Lindbom L, Haeggström JZ. Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C4 Synthase. J Pharmacol Exp Ther. 2015 Oct;355(1):108-16. doi: 10.1124/jpet.115.227157. Epub 2015 Aug 17. PubMed PMID: 26283693.

17: Rodríguez-Gómez R, Zafra-Gómez A, Dorival-García N, Ballesteros O, Navalón A. Determination of benzophenone-UV filters in human milk samples using ultrasound-assisted extraction and clean-up with dispersive sorbents followed by UHPLC-MS/MS analysis. Talanta. 2015 Mar;134:657-664. doi: 10.1016/j.talanta.2014.12.004. Epub 2014 Dec 16. PubMed PMID: 25618719.

18: Liu H, Sun P, Liu H, Yang S, Wang L, Wang Z. Acute toxicity of benzophenone-type UV filters for Photobacterium phosphoreum and Daphnia magna: QSAR analysis, interspecies relationship and integrated assessment. Chemosphere. 2015 Sep;135:182-8. doi: 10.1016/j.chemosphere.2015.04.036. Epub 2015 May 15. PubMed PMID: 25950412.

19: Wu BL, Zou HL, Qin FM, Li HY, Zhou GX. New Ent-Kaurane-Type Diterpene Glycosides and Benzophenone from Ranunculus muricatus Linn. Molecules. 2015 Dec 15;20(12):22445-53. doi: 10.3390/molecules201219801. PubMed PMID: 26694331.

20: Lee SY, Yasuda T, Yang YS, Zhang Q, Adachi C. Luminous butterflies: efficient exciton harvesting by benzophenone derivatives for full-color delayed fluorescence OLEDs. Angew Chem Int Ed Engl. 2014 Jun 16;53(25):6402-6. doi: 10.1002/anie.201402992. Epub 2014 May 18. PubMed PMID: 24839234.

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