UCB9608
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H555286

CAS#: 1616413-96-7

Description: UCB9608 is a Potent, Orally Bioavailable PI4KIIIβ Inhibitor. UCB9608 showed the improved metabolic stability and excellent pharmacokinetic profile. UCB9608 is an 11 nM PI4KIIIβ inhibitor that inhibits the HuMLR response with IC50 = 37 nM. Its potency and excellent ADME properties make it an ideal compound for future use as an in vitro and in vivo probe to elucidate the emerging role of PI4KIIIβ inhibition in immune processes.

Chemical Structure

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UCB9608
CAS# 1616413-96-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H555286
Name: UCB9608
CAS#: 1616413-96-7
Chemical Formula: C20H26N8O2
Exact Mass: 410.22
Molecular Weight: 410.482
Elemental Analysis: C, 58.52; H, 6.38; N, 27.30; O, 7.80

Price and Availability

Size Price Availability Quantity
25mg USD 250 2 Weeks
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3850 2 Weeks
2g USD 6450 2 Weeks
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Synonym: UCB9608; UCB-9608; UCB 9608.

IUPAC/Chemical Name: (3S)-4-(6-amino-1-methyl-pyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methyl-phenyl)-3-methyl-piperazine-1-carboxamide

InChi Key: WRONAJQPZWDYAR-ZDUSSCGKSA-N

InChi Code: InChI=1S/C20H26N8O2/c1-12-9-14(30-4)5-6-16(12)23-20(29)27-7-8-28(13(2)11-27)18-15-10-22-26(3)17(15)24-19(21)25-18/h5-6,9-10,13H,7-8,11H2,1-4H3,(H,23,29)(H2,21,24,25)/t13-/m0/s1

SMILES Code: O=C(N1C[C@H](C)N(C2=C3C(N(C)N=C3)=NC(N)=N2)CC1)NC4=CC=C(OC)C=C4C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 410.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Reuberson J, Horsley H, Franklin RJ, Ford D, Neuss J, Brookings D, Huang Q,
Vanderhoydonck B, Gao LJ, Jang M, Herdewijn P, Ghawalkar A, Fallah-Arani F, Khan
A, Henshall J, Jairaj M, Malcolm S, Ward E, Shuttleworth L, Lin Y, Li S, Louat T,
Waer M, Herman J, Payne A, Ceska T, Doyle C, Pitt WR, Calmiano M, Augustin M,
Steinbacher S, Lammens A, Allen R. Discovery of a potent, orally bioavailable
PI4KIIIβ inhibitor (UCB9608) able to significantly prolong allogeneic organ
engraftment in vivo. J Med Chem. 2018 Jun 28. doi: 10.1021/acs.jmedchem.8b00521.
[Epub ahead of print] PubMed PMID: 29952567.