Dibutyltin dilaurate
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H598294

CAS#: 77-58-7

Description: Dibutyltin dilaurate is used in prevention of parasitic dieases in cattle and sheep.

Chemical Structure

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Dibutyltin dilaurate
CAS# 77-58-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H598294
Name: Dibutyltin dilaurate
CAS#: 77-58-7
Chemical Formula: C32H64O4Sn
Exact Mass: 632.38
Molecular Weight: 631.570
Elemental Analysis: C, 60.86; H, 10.21; O, 10.13; Sn, 18.80

Price and Availability

Size Price Availability Quantity
25g USD 350 2 weeks
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Synonym: Dibutyltin dilaurate; Mark 1038; T 12; T-12; KS 20; DBTL; Stabilizer D-22; Lauric acid, dibutyltin deriv.;

IUPAC/Chemical Name: dibutylstannanediyl didodecanoate

InChi Key: UKLDJPRMSDWDSL-UHFFFAOYSA-L

InChi Code: InChI=1S/2C12H24O2.2C4H9.Sn/c2*1-2-3-4-5-6-7-8-9-10-11-12(13)14;2*1-3-4-2;/h2*2-11H2,1H3,(H,13,14);2*1,3-4H2,2H3;/q;;;;+2/p-2

SMILES Code: CCCCCCCCCCCC(O[Sn](CCCC)(CCCC)OC(CCCCCCCCCCC)=O)=O

Appearance: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 631.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jin M, Song P, Li N, Li X, Chen J. A plastic stabilizer dibutyltin dilaurate induces subchronic neurotoxicity in rats. Neural Regen Res. 2012 Oct 5;7(28):2213-20. doi: 10.3969/j.issn.1673-5374.2012.028.007. PubMed PMID: 25538742; PubMed Central PMCID: PMC4268721.

2: George GM, Frahm LJ, McDonnell JP. Atomic absorption spectrophotometric determination of dibutyltin dilaurate in finished feeds: collaborative study. J Assoc Off Anal Chem. 1977 Sep;60(5):1054-8. PubMed PMID: 893325.

3: Alam MS, Husain R, Seth PK, Srivastava SP. Age and sex related behavioral changes induced by dibutyltin-dilaurate in rats. Bull Environ Contam Toxicol. 1993 Feb;50(2):286-92. PubMed PMID: 8422532.

4: Khaliq MA, Husain R, Seth PK, Srivastava SP. Effect of dibutyltin dilaurate on regional brain polyamines in rats. Toxicol Lett. 1991 Feb;55(2):179-83. PubMed PMID: 1998205.

5: Subramoniam A, Husain R, Seth PK. Reduction of phosphoinositides and diacylglycerol levels in repeatedly dibutyltin-dilaurate-treated rat brain. Toxicol Lett. 1991 Aug;57(3):245-50. PubMed PMID: 1652800.

6: Subramoniam A, Khandelwal S, Dwivedi PD, Khanna S, Shanker R. Dibutyltin dilaurate induced thymic atrophy and modulation of phosphoinositide pathway of cell signalling in thymocytes of rats. Immunopharmacol Immunotoxicol. 1994 Nov;16(4):645-77. PubMed PMID: 7876466.

7: Shlosberg A, Held S, Bircz R. Poisoning of palm doves with dibutyltin dilaurate. J Am Vet Med Assoc. 1978 Nov 1;173(9):1183-4. PubMed PMID: 738943.

8: Shlosberg A, Egyed MN. Mass poisoning in cattle, palm doves and mink caused by the coccidiostat dibutyltin dilaurate. Vet Hum Toxicol. 1979 Feb;21(1):1-3. PubMed PMID: 425288.

9: Renault B, Cloutet E, Cramail H, Hannachi Y, Tassaing T. A combined spectroscopic and theoretical study of dibutyltin diacetate and dilaurate in supercritical CO2. J Phys Chem A. 2008 Sep 11;112(36):8379-86. doi: 10.1021/jp8004822. Epub 2008 Aug 15. PubMed PMID: 18707063.

10: Sandig B, Michalek L, Vlahovic S, Antonovici M, Hauer B, Buchmeiser MR. A Monolithic Hybrid Cellulose-2.5-Acetate/Polymer Bioreactor for Biocatalysis under Continuous Liquid-Liquid Conditions Using a Supported Ionic Liquid Phase. Chemistry. 2015 Oct 26;21(44):15835-42. doi: 10.1002/chem.201501618. Epub 2015 Sep 10. PubMed PMID: 26493884.

11: Zhang S, Wang L, Wang Z, Fan D, Shi L, Liu J. Derivation of freshwater water quality criteria for dibutyltin dilaurate from measured data and data predicted using interspecies correlation estimate models. Chemosphere. 2017 Mar;171:142-148. doi: 10.1016/j.chemosphere.2016.12.046. Epub 2016 Dec 12. PubMed PMID: 28013075.

12: Ohhira S, Matsui H. [Determination of dibutyltin compounds in polyvinyl chloride resin by capillary gas chromatography]. Nihon Eiseigaku Zasshi. 1989 Feb;43(6):1069-74. Japanese. PubMed PMID: 2746975.

13: Alam MS, Husain R, Srivastava SP, Seth PK. Influence of di-butyltin dilaurate on brain neurotransmitter systems and behavior in rats. Arch Toxicol. 1988 Apr;61(5):373-7. PubMed PMID: 2899427.

14: Mushtaq M, Mukhtar H, Datta KK, Tandon SG, Seth PK. Toxicological studies of a leachable stabilizer di-n-butyltin dilaurate(DBTL): effects on hepatic drug metabolizing enzyme activities. Drug Chem Toxicol. 1981;4(1):75-88. PubMed PMID: 7261948.

15: Pinna D, Salvadori B, Galeotti M. Monitoring the performance of innovative and traditional biocides mixed with consolidants and water-repellents for the prevention of biological growth on stone. Sci Total Environ. 2012 Apr 15;423:132-41. doi: 10.1016/j.scitotenv.2012.02.012. Epub 2012 Mar 7. PubMed PMID: 22401787.

16: Milton FA, Lacerda MG, Sinoti SBP, Mesquita PG, Prakasan D, Coelho MS, de Lima CL, Martini AG, Pazzine GT, Borin MF, Amato AA, Neves FAR. Dibutyltin Compounds Effects on PPARγ/RXRα Activity, Adipogenesis, and Inflammation in Mammalians Cells. Front Pharmacol. 2017 Aug 2;8:507. doi: 10.3389/fphar.2017.00507. eCollection 2017. PubMed PMID: 28824431; PubMed Central PMCID: PMC5539189.

17: Qiao X, Li Y, Mai J, Ji X, Li Q. Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells. Molecules. 2018 Jul 6;23(7). pii: E1654. doi: 10.3390/molecules23071654. PubMed PMID: 29986449.

18: Zhu R, Wang Y, Zhang Z, Ma D, Wang X. Synthesis of polycarbonate urethane elastomers and effects of the chemical structures on their thermal, mechanical and biocompatibility properties. Heliyon. 2016 Jun 22;2(6):e00125. doi: 10.1016/j.heliyon.2016.e00125. eCollection 2016 Jun. PubMed PMID: 27441296; PubMed Central PMCID: PMC4946310.

19: Shuaibu MN, Kanbara H, Yanagi T, Ichinose A, Ameh DA, Bonire JJ, Nok AJ. In vitro trypanocidal activity of dibutyltin dichloride and its fatty acid derivatives. Parasitol Res. 2003 Sep;91(1):5-11. Epub 2003 Jul 8. PubMed PMID: 12851812.

20: Sardon H, Engler AC, Chan JM, García JM, Coady DJ, Pascual A, Mecerreyes D, Jones GO, Rice JE, Horn HW, Hedrick JL. Organic acid-catalyzed polyurethane formation via a dual-activated mechanism: unexpected preference of N-activation over O-activation of isocyanates. J Am Chem Soc. 2013 Oct 30;135(43):16235-41. doi: 10.1021/ja408641g. Epub 2013 Oct 22. PubMed PMID: 24083673.