Coumatetralyl
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H461175

CAS#: 5836-29-3

Description: Coumatetralyl is an anticoagulant of the 4-hydroxycoumarin vitamin K antagonist type used as a rodenticide.

Chemical Structure

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Coumatetralyl
CAS# 5836-29-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H461175
Name: Coumatetralyl
CAS#: 5836-29-3
Chemical Formula: C19H16O3
Exact Mass: 292.11
Molecular Weight: 292.330
Elemental Analysis: C, 78.06; H, 5.52; O, 16.42

Price and Availability

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250mg USD 350 2 Weeks
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Synonym: Coumatetralyl; Endox; Racumin; Endrocide;

IUPAC/Chemical Name: 4-hydroxy-3-(1,2,3,4-tetrahydronaphthalen-1-yl)-2H-chromen-2-one

InChi Key: ULSLJYXHZDTLQK-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H16O3/c20-18-15-9-3-4-11-16(15)22-19(21)17(18)14-10-5-7-12-6-1-2-8-13(12)14/h1-4,6,8-9,11,14,20H,5,7,10H2

SMILES Code: O=c1c(C2CCCc3ccccc32)c(O)c(cccc4)c4o1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 292.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Andru J, Cosson JF, Caliman JP, Benoit E. Coumatetralyl resistance of Rattus tanezumi infesting oil palm plantations in Indonesia. Ecotoxicology. 2013 Mar;22(2):377-86. doi: 10.1007/s10646-012-1032-y. Epub 2012 Dec 21. PubMed PMID: 23264020.

2: Kay A, Chiu L, Chong CA. An unexpected case of coumarin poisoning with coumatetralyl. BMJ Case Rep. 2011 Apr 13;2011. pii: bcr0520102992. doi: 10.1136/bcr.05.2010.2992. PubMed PMID: 22701001; PubMed Central PMCID: PMC3079478.

3: Park C, Lim CY, Kim JH, Jang JI, Park HM. Successful therapy of coumatetralyl rodenticide induced pericardial effusion with pericardiocentesis in a dog. Can Vet J. 2011 Feb;52(2):165-8. PubMed PMID: 21532823; PubMed Central PMCID: PMC3022455.

4: Joffe D. Coumatetralyl rodenticide induced pericardial effusion - a comment. Can Vet J. 2011 Jun;52(6):577; author reply 577. PubMed PMID: 22131571; PubMed Central PMCID: PMC3095151.

5: Shimshoni JA, Soback S, Cuneah O, Shlosberg A, Britzi M. New validated multiresidue analysis of six 4-hydroxy-coumarin anticoagulant rodenticides in hen eggs. J Vet Diagn Invest. 2013 Nov;25(6):736-43. doi: 10.1177/1040638713501510. Epub 2013 Sep 30. PubMed PMID: 24081927.

6: Jin MC, Ma JM, Wang L, Chen XH. [Solid phase extraction--HPLC in determination of coumatetralyl in urine]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2006 Nov;24(11):682-3. Chinese. PubMed PMID: 17181951.

7: Dimuccio A, Camoni I, Vergori L, Dommarco R, Attard Barbini D, Vergori F, Ausili A, Santilio A. Screening for coumatetralyl in soft drinks by solid-matrix extraction and high-performance liquid chromatography with diode-array detection. J Chromatogr. 1991 Aug 16;553(1-2):305-9. PubMed PMID: 1787161.

8: Chopra G, Parshad VR. Evaluation of coumatetralyl against two predominant murid species. J Hyg (Lond). 1985 Jun;94(3):327-30. PubMed PMID: 4008919; PubMed Central PMCID: PMC2129486.

9: Greaves JH, Ayres P. Some rodenticidal properties of coumatetralyl. J Hyg (Lond). 1969 Jun;67(2):311-5. PubMed PMID: 5255887; PubMed Central PMCID: PMC2130717.

10: Rowe FP, Redfern R. Comparative toxicity of the two anti-coagulants, coumatetralyl and warfarin, to wild house-mice (Mus musculus L.). Ann Appl Biol. 1968 Dec;62(3):355-61. PubMed PMID: 5731720.

11: Lambert O, Pouliquen H, Larhantec M, Thorin C, L'Hostis M. Exposure of raptors and waterbirds to anticoagulant rodenticides (difenacoum, bromadiolone, coumatetralyl, coumafen, brodifacoum): epidemiological survey in Loire Atlantique (France). Bull Environ Contam Toxicol. 2007 Jul;79(1):91-4. Epub 2007 May 9. PubMed PMID: 17487436.

12: Bell RG, Caldwell PT, Holm EE. Coumarins and the vitamin K-K epoxide cycle. Lack of resistance to coumatetralyl in warfarin-resistant rats. Biochem Pharmacol. 1976 May 1;25(9):1067-70. PubMed PMID: 1267852.

13: Gómez-Canela C, Barata C, Lacorte S. Occurrence, elimination, and risk of anticoagulant rodenticides and drugs during wastewater treatment. Environ Sci Pollut Res Int. 2014;21(11):7194-203. doi: 10.1007/s11356-014-2714-1. Epub 2014 Mar 14. PubMed PMID: 24622989.

14: Dobson KJ. Coumatetralyl poisoning in pigs and effectiveness of vitamin K1. Aust Vet J. 1973 Feb;49(2):98-100. PubMed PMID: 4693823.

15: Gómez-Canela C, Lacorte S. Comprehensive characterization of anticoagulant rodenticides in sludge by liquid chromatography-tandem mass spectrometry. Environ Sci Pollut Res Int. 2016 Aug;23(15):15739-48. doi: 10.1007/s11356-016-6743-9. Epub 2016 May 4. PubMed PMID: 27146526.

16: Endepols S, Klemann N, Richter D, Matuschka FR. The potential of coumatetralyl enhanced by cholecalciferol in the control of anticoagulant-resistant Norway rats (Rattus norvegicus). Pest Manag Sci. 2017 Feb;73(2):280-286. doi: 10.1002/ps.4235. Epub 2016 Feb 19. PubMed PMID: 26800251.

17: Schaff JE, Montgomery MA. An HPLC-HR-MS-MS method for identification of anticoagulant rodenticides in blood. J Anal Toxicol. 2013 Jul-Aug;37(6):321-5. doi: 10.1093/jat/bkt036. Epub 2013 May 10. PubMed PMID: 23667199.

18: Muscarella M, Armentano A, Iammarino M, Palermo C, Amorena M. Anticoagulant rodenticide poisoning in animals of Apulia and Basilicata, Italy. Vet Ital. 2016 Jun 30;52(2):153-9. doi: 10.12834/VetIt.118.333.3. PubMed PMID: 27393877.

19: Vandenbroucke V, Bousquet-Melou A, De Backer P, Croubels S. Pharmacokinetics of eight anticoagulant rodenticides in mice after single oral administration. J Vet Pharmacol Ther. 2008 Oct;31(5):437-45. doi: 10.1111/j.1365-2885.2008.00979.x. PubMed PMID: 19000263.

20: Saito S, Sakai T, Nemoto S, Matsuda R. [Determination of 4-hydroxycoumarin rodenticides in animal products, fishery products, and honey by liquid chromatography-tandem mass spectrometry]. Shokuhin Eiseigaku Zasshi. 2011;52(4):244-50. Japanese. PubMed PMID: 21873815.