Allapinin
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Hodoodo CAT#: H598393

CAS#: 97792-45-5

Description: Allapinin is a potential antitumor agent agent that induces HL-60 differentiation and apoptosis with analgesic activity as well.

Chemical Structure

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Allapinin
CAS# 97792-45-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H598393
Name: Allapinin
CAS#: 97792-45-5
Chemical Formula: C32H45BrN2O8
Exact Mass: 0.00
Molecular Weight: 665.620
Elemental Analysis: C, 57.74; H, 6.81; Br, 12.00; N, 4.21; O, 19.23

Price and Availability

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500mg USD 270
1g USD 1150
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Synonym: Allapinin; Lappaconiti hydrobromidum; Lappaconitine hydrobromide; Allapinine;

IUPAC/Chemical Name: (3S,6S,6aS,7S,7aS,8S,9R,10S,11aS,12S,12aR,14S)-1-ethyl-7a,11a-dihydroxy-6,8,10-trimethoxydodecahydro-2H-3,6a,12-(epiethane[1,1,2]triyl)-7,9-methanonaphtho[2,3-b]azocin-3(4H)-yl 2-acetamidobenzoate hydrobromide

InChi Key: CFFYROOPXPKMEQ-IPZKEBFRSA-N

InChi Code: InChI=1S/C32H44N2O8.BrH/c1-6-34-16-29(42-28(36)18-9-7-8-10-21(18)33-17(2)35)12-11-25(40-4)31-23(29)14-20(26(31)34)30(37)15-22(39-3)19-13-24(31)32(30,38)27(19)41-5;/h7-10,19-20,22-27,37-38H,6,11-16H2,1-5H3,(H,33,35);1H/t19-,20+,22+,23-,24+,25+,26-,27+,29-,30+,31+,32+;/m1./s1

SMILES Code: CCN1C[C@]2(OC(c3c(NC(C)=O)cccc3)=O)CC[C@H](OC)[C@@]45[C@@H]2C[C@H]([C@@]6(O)C[C@H](OC)[C@H]7C[C@@H]5[C@]6(O)[C@H]7OC)[C@H]41.Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 665.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sokolov SF, Bakalov SA, Mironova NA, Rogova MM, Malkina TA, Golitsyn SP. [Efficiency and safety of allapinin in short- and long-term treatment of patients with normal heart and ventricular premature beats]. Kardiologiia. 2014;54(1):20-6. Russian. PubMed PMID: 24881307.

2: Sokolov SF, Dzhakhangirov FN. [Antiarrhythmic drug allapinin: review of results of clinical investigation]. Kardiologiia. 2002;42(7):96-102. Review. Russian. PubMed PMID: 12494120.

3: Sokolov SF, Golitsyn SP, Malakhov VI, Mikhaĭlova GA, Bankuzov VA. [Effect of allapinin on the function of the atrioventricular conduction system of the heart]. Kardiologiia. 1988 Nov;28(11):90-5. Russian. PubMed PMID: 3230785.

4: Valeev AE, Verkhratskiĭ AN, Dzhakhangirov FN. [Effects of allapinin on sodium currents in isolated neurons of the trigeminal ganglia and cardiomyocytes of rats]. Biull Eksp Biol Med. 1991 Apr;111(4):388-90. Russian. PubMed PMID: 1893144.

5: Asymbekova EU, Bunin IuA, Pomerantsev EV, Firstova MI, Bakashvili NG. [Effect of Ritmilen and allapinin on central hemodynamics and myocardial contractility of patients with heart rhythm disorders]. Kardiologiia. 1987 Apr;27(4):68-71. Russian. PubMed PMID: 3155396.

6: Erlikh AD. [The Study of Evidence Base for the Use of Lappaconitine Hydrobromide in Patients With Atrial Fibrillation]. Kardiologiia. 2016 Mar;56(3):48-53. Russian. PubMed PMID: 28294889.

7: Cherednik IL, Sheikh-Zade IuP, Galenko-Iaroshevskiĭ PA. [Analysis of anti-arrhythmic effect of allapinin during neurogenic atrial fibrillation]. Biull Eksp Biol Med. 1999 Feb;127(2):174-6. Russian. PubMed PMID: 10095948.

8: Kurbanov RD, Abdullaev TA. [Pharmacodynamics and the effectiveness of allapinin in patients with arrhythmia]. Klin Med (Mosk). 1988 Oct;66(10):52-5. Russian. PubMed PMID: 3070154.

9: Khakimov AG, Semeikin OV, Merkulova IN, Frolova EP, Mazaev AV. [Allapinin pharmacokinetics after its single intravenous administration]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1989;12(1):31-6. Russian. PubMed PMID: 2663028.

10: Abdalla A, Mazur NA, Sumarokov AB, Iavorskaia NV. [Comparative study of the effectiveness of allapinin in patients with frequent and stable extrasystole]. Kardiologiia. 1988 Nov;28(11):95-7. Russian. PubMed PMID: 2466144.

11: Abdalla A, Rulin VA, Mazur NA, Sumarokov AB, Chikovani SI. [Pharmacokinetics and pharmacodynamics of the new Russian anti-arrhythmia drug allapinin]. Kardiologiia. 1989 Jan;29(1):32-6. Russian. PubMed PMID: 2471868.

12: Suleĭmanova EU, Dzhakhangirov FN, Agaev RA, Petriakova ON, Globenko LA. [Data for hygienic standardization of allapinin in the working zone air]. Gig Tr Prof Zabol. 1991;(1):30-1. Russian. PubMed PMID: 2060816.

13: Smetnev AS, Golitsyn SP, Levin ER, Sokolov SF, Koltunova MI. [Study of the comparative anti-arrhythmic effectiveness of allapinin, ethacizine and mexitil in patients with ventricular disorders of cardiac rhythm]. Ter Arkh. 1988;60(8):34-8. Russian. PubMed PMID: 3067410.

14: Osipov MA, Bashchinskiĭ SE, Bart BIa. [Study of hemodynamic effects of allapinin and metoprolol using continuous wave Doppler echocardiography at rest and during physical exercise in patients with paroxysmal supraventricular tachycardia]. Kardiologiia. 1991 Aug;31(8):83-6. Russian. PubMed PMID: 1795486.

15: Abdalla A, Rulin VA, Mazur NA. [Biological availability of the new anti-arrhythmia drug allapinin in a tablet form]. Kardiologiia. 1990 Feb;30(2):95-7. Russian. PubMed PMID: 2190042.

16: Sokolov SF, Alikhanov GN, Golitsyn SP, Dzhakhangirov FN, Smetnev AS. [Effect of allapinin after a single intravenous administration to patients with chronic ventricular extrasystole]. Kardiologiia. 1988 Feb;28(2):46-52. Russian. PubMed PMID: 2453700.

17: Golitsyn SP, Sokolov SF, Alikhanov GN, Malakhov VI, Smetnev AS. [Our initial experience in using allapinin in patients with paroxysmal supraventricular tachycardias]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1989;12(2):94-7. Russian. PubMed PMID: 2604894.

18: Sokolov SF, Golitsyn SP, Manakhov VI, Zagraĭ AA, Bankuzov VA, Smetnev AS. [Electrophysiological mechanisms of the effect of allapinin in patients with paroxysmal supraventricular tachycardia]. Kardiologiia. 1991 Mar;31(3):38-42. Russian. PubMed PMID: 1875595.

19: Sokolov SF, Alikhanov GN, Golitsyn SP, Koltunova MI, Smetnev AS. [Effect of a single oral dose of allapinin in patients with chronic ventricular extrasystole]. Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR. 1989;12(1):36-42. Russian. PubMed PMID: 2472819.

20: Zamotaev IuN, Kremnev IuA, Grinenko NA, Podshibiakin SE. [Assessment of anti-arrhythmic efficacy of a domestic drug allapinin in patients with ischemic heart disease and cardiac arrhythmia]. Klin Med (Mosk). 2003;81(11):51-4. Russian. PubMed PMID: 14689712.