Pancopride

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H598418

CAS#: 121650-80-4

Description: Pancopride is a selective 5-HT3 receptor antagonist; effective against anticancer drug-evoked emesis.


Chemical Structure

img
Pancopride
CAS# 121650-80-4

Theoretical Analysis

Hodoodo Cat#: H598418
Name: Pancopride
CAS#: 121650-80-4
Chemical Formula: C18H24ClN3O2
Exact Mass: 349.16
Molecular Weight: 349.850
Elemental Analysis: C, 61.80; H, 6.91; Cl, 10.13; N, 12.01; O, 9.15

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Pancopride; Pancopridum; LAS 30451; LAS-30451; LAS30451;

IUPAC/Chemical Name: 4-amino-5-chloro-2-(cyclopropylmethoxy)-N-(quinuclidin-3-yl)benzamide

InChi Key: DBQMQBCSKXTCIJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H24ClN3O2/c19-14-7-13(17(8-15(14)20)24-10-11-1-2-11)18(23)21-16-9-22-5-3-12(16)4-6-22/h7-8,11-12,16H,1-6,9-10,20H2,(H,21,23)

SMILES Code: O=C(NC1CN2CCC1CC2)C3=CC(Cl)=C(N)C=C3OCC4CC4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 349.85 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Dewland P, Pérez Campos A, Martinez-Tobed A. Single dose pharmacokinetics and tolerance of pancopride in healthy volunteers. Arzneimittelforschung. 1995 Feb;45(2):177-83. PubMed PMID: 7710444.

2: Grande L, Lacima G, Pérez A, Zayas JM. Lack of effect of a 5-HT3 antagonist, pancopride, on lower oesophageal sphincter pressure in volunteers. Br J Clin Pharmacol. 1995 Oct;40(4):401-3. PubMed PMID: 8554943; PubMed Central PMCID: PMC1365160.

3: Fernández AG, Puig J, Beleta J, Doménech T, Bou J, Berga P, Gristwood RW, Roberts DJ. Pancopride, a potent and long-acting 5-HT3 receptor antagonist, is orally effective against anticancer drug-evoked emesis. Eur J Pharmacol. 1992 Nov 10;222(2-3):257-64. PubMed PMID: 1451737.

4: Salva P, Costa J, Pérez-Campos A, Martínez-Tobed A. Repeated dose pharmacokinetics of pancopride in human volunteers. Biopharm Drug Dispos. 1994 Nov;15(8):643-51. PubMed PMID: 7888596.

5: Aranda E, Barneto IC, Rubio MJ, Gonzalez R, Garcia A, Perez A. Prevention of highly emetogenic chemotherapy-induced vomiting: a double blind, randomized crossover study to compare pancopride (LAS 30451) and pancopride plus dexamethasone. Tumori. 1995 Nov-Dec;81(6):432-4. PubMed PMID: 8804470.

6: Pérez Campos A. [The clinical development of an antiemetic in oncology. A meta-analysis]. Med Clin (Barc). 1994 Sep 17;103(8):281-6. Spanish. PubMed PMID: 7967877.

7: Martin M, Rosell R, Guillem V, Díaz-Rubio E, Moreno I, Soriano V, Fernández A, Pérez A. LAS 30451: a novel 5-HT3 antagonist. Eur J Cancer. 1993;29A Suppl 1:S33-4. PubMed PMID: 8427723.