WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H461209
CAS#: 1165-48-6
Description: Dimefline is a potent pneumokinetic agent, has been effectively used orally and by injection in patients suffering from bronchial asthma.
Hodoodo Cat#: H461209
Name: Dimefline
CAS#: 1165-48-6
Chemical Formula: C20H21NO3
Exact Mass: 323.15
Molecular Weight: 323.390
Elemental Analysis: C, 74.28; H, 6.55; N, 4.33; O, 14.84
This product is not in stock, which may be available by custom synthesis.
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Synonym: Dimefline; Malivan; Reanimil;
IUPAC/Chemical Name: 8-((dimethylamino)methyl)-7-methoxy-3-methyl-2-phenyl-4H-chromen-4-one
InChi Key: ZXFQRFXLFWWKLX-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H21NO3/c1-13-18(22)15-10-11-17(23-4)16(12-21(2)3)20(15)24-19(13)14-8-6-5-7-9-14/h5-11H,12H2,1-4H3
SMILES Code: O=C1C(C)=C(C2=CC=CC=C2)OC3=C1C=CC(OC)=C3CN(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 323.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Delbeke FT, Debackere M. The influence of diuretics on the excretion and metabolism of doping agents--V. Dimefline. J Pharm Biomed Anal. 1991;9(1):23-8. PubMed PMID: 2043718.
2: Huang Q, Zhang JR. [Mechanism of dimefline]. Sheng Li Ke Xue Jin Zhan. 1985 Oct;16(4):353-5. Review. Chinese. PubMed PMID: 3016888.
3: SETNIKAR I, MAGISTRETTI MJ. CARDIAC EFFECTS OF DIMEFLINE COMPARED WITH THOSE OF OTHER CENTRAL NERVOUS SYSTEM STIMULANTS. Arch Int Pharmacodyn Ther. 1964 Sep 1;151:200-16. PubMed PMID: 14205414.
4: KUEBLER WF Jr, BENDURE JD. THE EFFECT OF DIMEFLINE ON ACUTE CANINE BARBITURATE DEPRESSION. Am J Vet Res. 1963 Nov;24:1227-31. PubMed PMID: 14081460.
5: SARTORELLI E, BARALDI V, ZEDDA S. [DIMEFLINE IN LARGE DOSES IN THE THERAPY OF THE SYNDROME OF CO-2 INTOXICATION IN PATIENTS WITH EMPHYSEMA AND WITH SILICOSIS]. Clin Ter. 1963 Sep 15;26:431-47. Italian. PubMed PMID: 14091909.
6: MILLER J. A NEW PNEUMOKINETIC DRUG (DIMEFLINE) IN THE TREATMENT OF BRONCHIAL ASTHMA. Dis Chest. 1964 Nov;46:545-7. PubMed PMID: 14228359.
7: BONZANINI C. [Dimefline in anesthesiological practice]. Minerva Anestesiol. 1962 Apr;28:163-5. Italian. PubMed PMID: 13871121.
8: SARTORELLI E, GRIECO A, MANCOSU A, ZEDDA S. [Analeptic activity of dimefline in emphysematous and silicotic patients with respiratory insufficiency]. Med Lav. 1961 Jun-Jul;52:455-62. Italian. PubMed PMID: 14497284.
9: BAUDRAZ B, VULLIEMOZ P, PIOLINO M. [Dimefline, a new respiratory analeptic. Experimentation and therapeutic applications in pulmonary emphysema]. Schweiz Med Wochenschr. 1962 Mar 10;92:294-300. French. PubMed PMID: 13865840.
10: DE GREGORIO G. [Study of the analeptic action of 3-methyl-7-methoxy-8-dimethylaminomethylflavone (dimefline)]. Gazz Med Ital. 1960 Nov;119:466-70. Italian. PubMed PMID: 13720534.
11: Huang Q, Lin RJ, Gong QL, Zhang JR. [Analysis of the excitatory effects of dimefline on respiration in rabbits]. Sheng Li Xue Bao. 1985 Aug;37(4):361-7. Chinese. PubMed PMID: 3837332.
12: BAILEY WP Jr, BRINKMAN GL. Evaluation of a new respiratory stimulant: Dimefline. Am J Med Sci. 1962 Dec;244:744-8. PubMed PMID: 13969027.
13: Biró Z, Kovách AG. [Effects of Karion, prethcamide and dimefline on respiration and blood circulation]. Acta Med Acad Sci Hung. 1969;26(4):329-43. German. PubMed PMID: 5393362.
14: AMRIS CJ, QUAADE F, SOLVSTEEN P. DIMEFLINE, A NEW RESPIRATORY ANALEPTIC. AIR ANALYSES ON ARTERIAL AND CAPILLARY BLOOD. Acta Anaesthesiol Scand. 1963;7:107-12. PubMed PMID: 14058018.
15: COLDING A, KROGSGAARD A, NORREGAARD S. DIMEFLINE, A NEW RESPIRATORY ANALEPTIC. PNEUMOTACHOGRAPHIC STUDIES ON PATIENTS WITH RESPIRATORY INSUFFICIENCY. Acta Anaesthesiol Scand. 1963;7:97-106. PubMed PMID: 14058024.
16: GUNELLA G, PETRELLA A, LORETI A. [Stimulation of the respiratory centers, by means of Dimefline, in the treatment of respiratory insufficiency]. G Clin Med. 1961 Sep;42:1011-21. Italian. PubMed PMID: 13902955.
17: SETNIKAR I, MURMANN W, MAGISTRETTI MJ. Dimefline (Rec 7-0267), other C.N.S. stimulants and lobeline as antagonists of pentobarbital. Arch Int Pharmacodyn Ther. 1962 Aug 1;138:364-88. PubMed PMID: 13988204.
18: Valenti P, Recanatini M, Da Re P, Cima L, Giusti P. Halogenated dimefline-type derivatives. Arch Pharm (Weinheim). 1983 May;316(5):421-6. PubMed PMID: 6135408.
19: Gautier J, Lamisse F, Lamagnère JP. [Assisted ventilation and dimefline (apropos of 15 cases)]. Therapeutique. 1969 Nov;45(9):921-5. French. PubMed PMID: 4391510.
20: SETNIKAR I, PATERLINI MR. FACTORS AFFECTING TOXICITY OF DIMEFLINE INTRAVENOUSLY INFUSED. Toxicol Appl Pharmacol. 1964 May;6:263-8. PubMed PMID: 14194757.
