ARRY-797

  • CAT# 555466
  • CAS# 1036404-17-7
  • Purity >98%

Price and availability

Structure

Structure of ARRY-797

CAS# 1036404-17-7

Pricing updated 2019-09-04 . Prices are subject to change without notice
Description:

ARRY-797, also known as ARRY-371797, is a potent and selective p38α inhibitor (p38 mitogen-activated protein kinase inhibitor). ARRY-371797 Inhibits LPS-Induced IL-6 and In Vivo Growth of RPMI-8226 Human Multiple Myeloma Cells.

Technical data

IUPAC/Chemnical Name5-(2,4-difluorophenoxy)-N-(2-(dimethylamino)ethyl)-1-isobutyl-1H -indazole-6-carboxamide
Synonym name ARRY-371797; ARRY 371797; ARRY371797; ARRY-797; ARRY 797; ARRY797
CAS#1036404-17-7
Molecule FormlaC22H26F2N4O2
Molecule Weight416.47
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage ConditionDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Stability>2 years if stored properly
Harmonized System (HS) Code 2934990300
SMILES code O=C(C1=CC2=C(C=C1OC3=CC=C(F)C=C3F)C=NN2CC(C)C)NCCN(C)C
InChi codeInChI=1S/C22H26F2N4O2/c1-14(2)13-28-19-11-17(22(29)25-7-8-27(3)4)21(9-15(19)12-26-28)30-20-6-5-16(23)10-18(20)24/h5-6,9-12,14H,7-8,13H2,1-4H3,(H,25,29)
InChi keyIFGWYHGYNVGVRB-UHFFFAOYSA-N

References

1: Carter D, Warsen A, Mandell K, Cuschieri J, Maier RV, Arbabi S. Delayed topical p38 MAPK inhibition attenuates full-thickness burn wound inflammatory signaling. J Burn Care Res. 2014 Mar-Apr;35(2):e83-92. doi: 10.1097/BCR.0b013e31828a8d6e. PubMed PMID: 23666384; PubMed Central PMCID: PMC4180234. 2: Muchir A, Wu W, Choi JC, Iwata S, Morrow J, Homma S, Worman HJ. Abnormal p38α mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A/C gene mutation. Hum Mol Genet. 2012 Oct 1;21(19):4325-33. doi: 10.1093/hmg/dds265. Epub 2012 Jul 5. PubMed PMID: 22773734; PubMed Central PMCID: PMC3441127. 3. http://www.bloodjournal.org/content/108/11/3478?sso-checked=true