AMG-510
- CAT# 207085
- CAS# 2252403-56-6
- Purity >98%
WARNING: This product is for research use only, not for human or veterinary use.
Price and availability
Structure
Structure of AMG-510
CAS# 2252403-56-6
Pricing updated 2019-09-04 . Prices are subject to change without notice
Description:
AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells
Technical data
IUPAC/Chemnical Name 4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one Synonym name AMG-510; AMG 510; AMG510 CAS# 2252403-56-6 Related CAS# 2296729-00-3 (racemate) 2252403-56-6 Molecule Formla C30H30F2N6O3 Molecule Weight 560.61 Appearance Solid powder Purity >98% (or refer to the Certificate of Analysis) Shipping Condition Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. Storage Condition Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stability >2 years if stored properly Harmonized System (HS) Code 2934.99.90.01 SMILES code O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1 InChi code InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 InChi key NXQKSXLFSAEQCZ-SFHVURJKSA-N
Structure
Structure of AMG-510
CAS# 2252403-56-6
Description:
AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells
Technical data
| IUPAC/Chemnical Name | 4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one |
| Synonym name | AMG-510; AMG 510; AMG510 |
| CAS# | 2252403-56-6 |
| Related CAS# | 2296729-00-3 (racemate) 2252403-56-6 |
| Molecule Formla | C30H30F2N6O3 |
| Molecule Weight | 560.61 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Stability | >2 years if stored properly |
| Harmonized System (HS) Code | 2934.99.90.01 |
| SMILES code | O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1 |
| InChi code | InChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1 |
| InChi key | NXQKSXLFSAEQCZ-SFHVURJKSA-N |