AMG-510

  • CAT# 207085
  • CAS# 2252403-56-6
  • Purity >98%

Price and availability

Structure

Structure of AMG-510

CAS# 2252403-56-6

Pricing updated 2019-09-04 . Prices are subject to change without notice
Description:

AMG-510 is a potent KRAS G12C covalent inhibitor. AMG-510 selectively targets the KRAS p.G12C mutant, at either the DNA, RNA or protein level, and prevents, through an as of yet not elucidated manner, expression of and/or tumor cell signaling through the KRAS p.G12C mutant. This may inhibit growth in KRAS p.G12C-expressing tumor cells

Technical data

IUPAC/Chemnical Name4-((S)-4-acryloyl-2-methylpiperazin-1-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(2-isopropyl-4-methylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2(1H)-one
Synonym nameAMG-510; AMG 510; AMG510
CAS#2252403-56-6
Related CAS#2296729-00-3 (racemate) 2252403-56-6
Molecule FormlaC30H30F2N6O3
Molecule Weight560.61
AppearanceSolid powder
Purity>98% (or refer to the Certificate of Analysis)
Shipping ConditionShipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage ConditionDry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Stability>2 years if stored properly
Harmonized System (HS) Code 2934.99.90.01
SMILES code O=C(C=C)N1C[C@H](C)N(C2=NC(N(C3=C(C)C=CN=C3C(C)C)C4=C2C=C(F)C(C5=C(O)C=CC=C5F)=N4)=O)CC1
InChi codeInChI=1S/C30H30F2N6O3/c1-6-23(40)36-12-13-37(18(5)15-36)28-19-14-21(32)26(24-20(31)8-7-9-22(24)39)34-29(19)38(30(41)35-28)27-17(4)10-11-33-25(27)16(2)3/h6-11,14,16,18,39H,1,12-13,15H2,2-5H3/t18-/m0/s1
InChi keyNXQKSXLFSAEQCZ-SFHVURJKSA-N