RFI-641

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H461271

CAS#: 197366-24-8

Description: RFI-641 is a small dendrimer-like compound with anti-RSV properties and is potent in vitro and in vivo activity.

Chemical Structure

img
RFI-641
CAS# 197366-24-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H461271
Name: RFI-641
CAS#: 197366-24-8
Chemical Formula: C58H60N24Na2O22S6
Exact Mass: 1,682.24
Molecular Weight: 1,683.600
Elemental Analysis: C, 41.38; H, 3.59; N, 19.97; Na, 2.73; O, 20.91; S, 11.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: RFI-641; RFI 641; RFI641;

IUPAC/Chemical Name: sodium 4,4'-bis((4,6-bis((3-(N-(2-((2-amino-2-oxoethyl)amino)-2-oxoethyl)sulfamoyl)phenyl)amino)-1,3,5-triazin-2-yl)amino)-[1,1'-biphenyl]-2,2'-disulfonate

InChi Key: KMNJIAUXWBFEIA-UHFFFAOYSA-L

InChi Code: InChI=1S/C58H62N24O22S6.2Na/c59-45(83)23-63-49(87)27-67-105(91,92)37-9-1-5-31(17-37)71-53-77-54(72-32-6-2-10-38(18-32)106(93,94)68-28-50(88)64-24-46(60)84)80-57(79-53)75-35-13-15-41(43(21-35)109(99,100)101)42-16-14-36(22-44(42)110(102,103)104)76-58-81-55(73-33-7-3-11-39(19-33)107(95,96)69-29-51(89)65-25-47(61)85)78-56(82-58)74-34-8-4-12-40(20-34)108(97,98)70-30-52(90)66-26-48(62)86;;/h1-22,67-70H,23-30H2,(H2,59,83)(H2,60,84)(H2,61,85)(H2,62,86)(H,63,87)(H,64,88)(H,65,89)(H,66,90)(H,99,100,101)(H,102,103,104)(H3,71,72,75,77,79,80)(H3,73,74,76,78,81,82);;/q;2*+1/p-2

SMILES Code: O=S(C1=CC(NC2=NC(NC3=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C3)=NC(NC4=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C4)=N2)=CC=C1C5=CC=C(NC6=NC(NC7=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C7)=NC(NC8=CC=CC(S(=O)(NCC(NCC(N)=O)=O)=O)=C8)=N6)C=C5S(=O)([O-])=O)([O-])=O.[Na+].[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,683.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Nikitenko AA, Raifeld YE, Wang TZ. The discovery of RFI-641 as a potent and selective inhibitor of the respiratory syncytial virus. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1041-4. PubMed PMID: 11327584.

2: Huntley CC, Weiss WJ, Gazumyan A, Buklan A, Feld B, Hu W, Jones TR, Murphy T, Nikitenko AA, O'Hara B, Prince G, Quartuccio S, Raifeld YE, Wyde P, O'Connell JF. RFI-641, a potent respiratory syncytial virus inhibitor. Antimicrob Agents Chemother. 2002 Mar;46(3):841-7. PubMed PMID: 11850270; PubMed Central PMCID: PMC127488.

3: Weiss WJ, Murphy T, Lynch ME, Frye J, Buklan A, Gray B, Lenoy E, Mitelman S, O'Connell J, Quartuccio S, Huntley C. Inhalation efficacy of RFI-641 in an African green monkey model of RSV infection. J Med Primatol. 2003 Apr;32(2):82-8. PubMed PMID: 12823630.

4: Razinkov V, Gazumyan A, Nikitenko A, Ellestad G, Krishnamurthy G. RFI-641 inhibits entry of respiratory syncytial virus via interactions with fusion protein. Chem Biol. 2001 Jul;8(7):645-59. PubMed PMID: 11451666.

5: Razinkov V, Huntley C, Ellestad G, Krishnamurthy G. RSV entry inhibitors block F-protein mediated fusion with model membranes. Antiviral Res. 2002 Jul;55(1):189-200. PubMed PMID: 12076763.