WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H461349
CAS#: 122173-74-4
Description: Mideplanin is a glycopeptide antibiotic.
Hodoodo Cat#: H461349
Name: Mideplanin
CAS#: 122173-74-4
Chemical Formula: C93H109Cl2N11O32
Exact Mass: 1,961.66
Molecular Weight: 1,963.840
Elemental Analysis: C, 56.88; H, 5.59; Cl, 3.61; N, 7.85; O, 26.07
This product is not in stock, which may be available by custom synthesis.
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Synonym: Mideplanin; Mdl 62873; Mdl-62873; Mdl62873;
IUPAC/Chemical Name: A name could not be generated for this structure.
InChi Key: KVZUWEFUEGGULL-UHFFFAOYSA-N
InChi Code: InChI=1S/C93H109Cl2N11O32/c1-38(2)11-8-6-7-9-12-65(115)100-73-79(120)76(117)63(36-108)135-92(73)138-83-60-30-45-31-61(83)132-57-20-16-43(28-52(57)95)82(137-91-72(98-39(3)110)78(119)75(116)62(35-107)134-91)74-90(129)104-71(86(125)97-21-10-22-106(4)5)50-33-47(112)34-59(133-93-81(122)80(121)77(118)64(37-109)136-93)66(50)49-27-42(15-17-54(49)113)68(87(126)105-74)102-89(128)70(45)103-88(127)69-44-25-46(111)32-48(26-44)130-58-29-41(14-18-55(58)114)67(96)85(124)99-53(84(123)101-69)24-40-13-19-56(131-60)51(94)23-40/h13-20,23,25-34,38,53,62-64,67-82,91-93,107-109,111-114,116-122H,6-12,21-22,24,35-37,96H2,1-5H3,(H,97,125)(H,98,110)(H,99,124)(H,100,115)(H,101,123)(H,102,128)(H,103,127)(H,104,129)(H,105,126)
SMILES Code: CC(CCCCCCC(NC1C(O)C(O)C(CO)OC1Oc2c(Oc3c(Cl)cc(C(OC4C(NC(C)=O)C(O)C(O)C(CO)O4)C5C(NC(C(NCCCN(C)C)=O)c6c(c7c(O)ccc(C(NC(C8NC(C9c%10cc(Oc%11c(O)ccc(C(N)C(NC(C(N9)=O)C%12)=O)c%11)cc(O)c%10)=O)=O)C(N5)=O)c7)c(OC%13C(O)C(O)C(O)C(CO)O%13)cc(O)c6)=O)cc3)cc8cc2Oc%14c(Cl)cc%12cc%14)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,963.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Venditti M, Tarasi A, Gelfusa V, Nicastri E, Penni A, Martino P. Antimicrobial susceptibilities of enterococci isolated from hospitalized patients. Antimicrob Agents Chemother. 1993 May;37(5):1190-2. PubMed PMID: 8517714; PubMed Central PMCID: PMC187931.
2: Treviño J, Bayón C, Ardá A, Marinelli F, Gandolfi R, Molinari F, Jimenez-Barbero J, Hernáiz MJ. New insights into glycopeptide antibiotic binding to cell wall precursors using SPR and NMR spectroscopy. Chemistry. 2014 Jun 10;20(24):7363-72. doi: 10.1002/chem.201303310. Epub 2014 May 7. PubMed PMID: 24805824.
3: Gandolfi R, Jovetic S, Marinelli F, Molinari F. Biotransformations of lipoglycopeptides to obtain novel antibiotics. J Antibiot (Tokyo). 2007 Apr;60(4):265-71. PubMed PMID: 17456978.
4: Goldstein BP, Candiani G, Arain TM, Romanò G, Ciciliato I, Berti M, Abbondi M, Scotti R, Mainini M, Ripamonti F, et al. Antimicrobial activity of MDL 63,246, a new semisynthetic glycopeptide antibiotic. Antimicrob Agents Chemother. 1995 Jul;39(7):1580-8. PubMed PMID: 7492108; PubMed Central PMCID: PMC162785.
5: Matera G, Berlinghieri MC, Barreca G, Focà A. In vitro effects of novel glycopeptide antibiotics on the reactivity of the lipopolysaccharide (LPS) of S. minnesota R595. New Microbiol. 1995 Jul;18(3):325-9. PubMed PMID: 7553371.