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Galactose
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H592646

CAS#: 3646-73-9

Description: Galactose prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin.

Chemical Structure

Galactose

CAS# 3646-73-9

Instruction

Theoretical Analysis

Hodoodo Cat#: H592646
Name: Galactose
CAS#: 3646-73-9
Chemical Formula: C6H12O6
Exact Mass: 180.06
Molecular Weight: 180.160
Elemental Analysis: C, 40.00; H, 6.71; O, 53.28

Price and Availability

Size	Price	Availability	Quantity
200mg	USD 1500
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: alpha-D-Galactose; Galactose

IUPAC/Chemical Name: Systematic Name alpha-D-Galactopyranose

InChi Key: WQZGKKKJIJFFOK-PHYPRBDBSA-N

InChi Code: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1

SMILES Code: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 180.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Coelho AI, Berry GT, Rubio-Gozalbo ME. Galactose metabolism and health. Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):422-7. doi: 10.1097/MCO.0000000000000189. Review. PubMed PMID: 26001656.

2: Schadewaldt P, Kamalanathan L, Hammen HW, Kotzka J, Wendel U. Endogenous galactose formation in galactose-1-phosphate uridyltransferase deficiency. Arch Physiol Biochem. 2014 Dec;120(5):228-39. doi: 10.3109/13813455.2014.962547. Epub 2014 Sep 30. PubMed PMID: 25268296.

3: Salkovic-Petrisic M, Osmanovic-Barilar J, Knezovic A, Hoyer S, Mosetter K, Reutter W. Long-term oral galactose treatment prevents cognitive deficits in male Wistar rats treated intracerebroventricularly with streptozotocin. Neuropharmacology. 2014 Feb;77:68-80. doi: 10.1016/j.neuropharm.2013.09.002. Epub 2013 Sep 18. PubMed PMID: 24055495.

4: Hobbs ME, Williams HJ, Hillerich B, Almo SC, Raushel FM. l-Galactose metabolism in Bacteroides vulgatus from the human gut microbiota. Biochemistry. 2014 Jul 22;53(28):4661-70. doi: 10.1021/bi500656m. Epub 2014 Jul 7. PubMed PMID: 24963813; PubMed Central PMCID: PMC4108180.

5: Kamthan M, Kamthan A, Ruhela D, Maiti P, Bhavesh NS, Datta A. Upregulation of galactose metabolic pathway by N-acetylglucosamine induced endogenous synthesis of galactose in Candida albicans. Fungal Genet Biol. 2013 May;54:15-24. doi: 10.1016/j.fgb.2013.02.006. Epub 2013 Feb 27. PubMed PMID: 23454545.

6: Bisha I, Rodriguez A, Laio A, Magistrato A. Metadynamics simulations reveal a Na+ independent exiting path of galactose for the inward-facing conformation of vSGLT. PLoS Comput Biol. 2014 Dec 18;10(12):e1004017. doi: 10.1371/journal.pcbi.1004017. eCollection 2014 Dec. PubMed PMID: 25522004; PubMed Central PMCID: PMC4270436.

7: Wang R, Wu XZ. Roles of galactose 3'-O- sulfation in signaling. Glycoconj J. 2014 Nov;31(8):549-54. doi: 10.1007/s10719-014-9558-2. Epub 2014 Oct 8. Review. PubMed PMID: 25294496.

8: Asano M. [Galactose-containing carbohydrates in the inflammation, development and nervous system]. Seikagaku. 2014 Jun;86(3):382-90. Review. Japanese. PubMed PMID: 25073377.

9: Nagy T, Frank D, Kátai E, Yahiro RK, Poór VS, Montskó G, Zrínyi Z, Kovács GL, Miseta A. Lithium induces ER stress and N-glycan modification in galactose-grown Jurkat cells. PLoS One. 2013 Jul 22;8(7):e70410. doi: 10.1371/journal.pone.0070410. Print 2013. PubMed PMID: 23894652; PubMed Central PMCID: PMC3718757.

10: Sakamoto Y, Ohta T, Ito Y. Stereoselective synthesis of UDP-2-(2-ketopropyl)galactose aided by di-tert-butylsilylene protecting group. Glycoconj J. 2015 Oct;32(7):541-8. doi: 10.1007/s10719-015-9581-y. Epub 2015 Mar 24. PubMed PMID: 25800650.

11: Phongsisay V, Iizasa E, Hara H, Yamasaki S. 3-O-sulfo-β-D-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5. Mol Immunol. 2015 Feb;63(2):595-9. doi: 10.1016/j.molimm.2014.07.023. Epub 2014 Aug 27. PubMed PMID: 25172093.

12: Mullins RJ, James H, Platts-Mills TA, Commins S. Relationship between red meat allergy and sensitization to gelatin and galactose-α-1,3-galactose. J Allergy Clin Immunol. 2012 May;129(5):1334-1342.e1. doi: 10.1016/j.jaci.2012.02.038. Epub 2012 Apr 3. PubMed PMID: 22480538; PubMed Central PMCID: PMC3340561.

13: Wang HW, Jiang PL, Lin SF, Lin HJ, Ou KL, Deng WP, Lee LW, Huang YY, Liang PH, Liu DZ. Application of galactose-modified liposomes as a potent antigen presenting cell targeted carrier for intranasal immunization. Acta Biomater. 2013 Mar;9(3):5681-8. doi: 10.1016/j.actbio.2012.11.007. Epub 2012 Nov 14. PubMed PMID: 23159567.

14: Yun EJ, Lee S, Kim JH, Kim BB, Kim HT, Lee SH, Pelton JG, Kang NJ, Choi IG, Kim KH. Enzymatic production of 3,6-anhydro-L-galactose from agarose and its purification and in vitro skin whitening and anti-inflammatory activities. Appl Microbiol Biotechnol. 2013 Apr;97(7):2961-70. doi: 10.1007/s00253-012-4184-z. Epub 2012 Jun 8. PubMed PMID: 22678025.

15: Dalkıran B, Erden PE, Kılıç E. Electrochemical biosensing of galactose based on carbon materials: graphene versus multi-walled carbon nanotubes. Anal Bioanal Chem. 2016 Jun;408(16):4329-39. doi: 10.1007/s00216-016-9532-x. Epub 2016 Apr 13. PubMed PMID: 27074783.

16: Ficicioglu C, Hussa C, Gallagher PR, Thomas N, Yager C. Monitoring of biochemical status in children with Duarte galactosemia: utility of galactose, galactitol, galactonate, and galactose 1-phosphate. Clin Chem. 2010 Jul;56(7):1177-82. doi: 10.1373/clinchem.2010.144097. Epub 2010 May 20. PubMed PMID: 20489133.

17: Fukasawa T, Abe A, Nakamura A, Horigome M, Naito A. Solid-state NMR spectroscopy reveals anomer specific transport of galactose in the milk yeast Kluyveromyces lactis. FEMS Yeast Res. 2012 Jun;12(4):415-22. doi: 10.1111/j.1567-1364.2012.00788.x. Epub 2012 Feb 13. PubMed PMID: 22239854.

18: Ioannou A, Cini E, Timofte RS, Flitsch SL, Turner NJ, Linclau B. Heavily fluorinated carbohydrates as enzyme substrates: oxidation of tetrafluorinated galactose by galactose oxidase. Chem Commun (Camb). 2011 Oct 28;47(40):11228-30. doi: 10.1039/c1cc13956h. Epub 2011 Sep 13. PubMed PMID: 21915393.

19: Godoy AS, Camilo CM, Kadowaki MA, Muniz HD, Espirito Santo M, Murakami MT, Nascimento AS, Polikarpov I. Crystal structure of β1→6-galactosidase from Bifidobacterium bifidum S17: trimeric architecture, molecular determinants of the enzymatic activity and its inhibition by α-galactose. FEBS J. 2016 Nov;283(22):4097-4112. doi: 10.1111/febs.13908. Epub 2016 Oct 18. PubMed PMID: 27685756.

20: Liu N, Yang M, Mao X, Mu B, Wei D. Molecular cloning and expression of a new α-neoagarobiose hydrolase from Agarivorans gilvus WH0801 and enzymatic production of 3,6-anhydro-l-galactose. Biotechnol Appl Biochem. 2016 Mar-Apr;63(2):230-7. doi: 10.1002/bab.1363. Epub 2015 May 24. PubMed PMID: 25676340. H

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