Leucokinin I
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Hodoodo CAT#: H598655

CAS#: 104600-89-7

Description: Leucokinin I is an eight amino acid neuropeptide found in the nervous system of the bowfly. Also isolated from head of Madeira cockroach Leucophaea maderae

Chemical Structure

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Leucokinin I
CAS# 104600-89-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H598655
Name: Leucokinin I
CAS#: 104600-89-7
Chemical Formula: C41H53N11O12
Exact Mass: 891.39
Molecular Weight: 891.940
Elemental Analysis: C, 55.21; H, 5.99; N, 17.27; O, 21.52

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1mg USD 350 2 Weeks
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Synonym: Leucokinin I; Asp-pro-ala-phe-asn-ser-trp-gly-NH2;

IUPAC/Chemical Name: (S)-4-((S)-2-(((5S,8S,11S,14S,17S)-5-((1H-indol-3-yl)methyl)-1-amino-11-(2-amino-2-oxoethyl)-14-benzyl-8-(hydroxymethyl)-1,4,7,10,13,16-hexaoxo-3,6,9,12,15-pentaazaoctadecan-17-yl)carbamoyl)pyrrolidin-1-yl)-3-amino-4-oxobutanoic acid

InChi Key: ADMFWPBDASJZNU-SKHNUPMMSA-N

InChi Code: 1S/C41H53N11O12/c1-21(47-40(63)31-12-7-13-52(31)41(64)25(42)16-34(56)57)35(58)48-27(14-22-8-3-2-4-9-22)37(60)50-29(17-32(43)54)38(61)51-30(20-53)39(62)49-28(36(59)46-19-33(44)55)15-23-18-45-26-11-6-5-10-24(23)26/h2-6,8-11,18,21,25,27-31,45,53H,7,12-17,19-20,42H2,1H3,(H2,43,54)(H2,44,55)(H,46,59)(H,47,63)(H,48,58)(H,49,62)(H,50,60)(H,51,61)(H,56,57)/t21-,25-,27-,28-,29-,30-,31-/m0/s1

SMILES Code: N[C@@H](CC(O)=O)C(N(CCC1)[C@@H]1C(N[C@@H](C)C(N[C@@H](Cc2ccccc2)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](Cc(c[nH]3)c4c3cccc4)C(NCC(N)=O)=O)=O)=O)=O)=O)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 891.94 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Elekes K, Hernádi L, Muren JE, Nässel DR. Peptidergic neurons in the snail Helix pomatia: distribution of neurons in the central and peripheral nervous systems that react with an antibody raised to the insect neuropeptide, leucokinin I. J Comp Neurol. 1994 Mar 8;341(2):257-72. PubMed PMID: 7513000.

2: Chen Y, Veenstra JA, Davis NT, Hagedorn HH. A comparative study of leucokinin-immunoreactive neurons in insects. Cell Tissue Res. 1994 Apr;276(1):69-83. PubMed PMID: 7910521.

3: Lundquist CT, Brodin E, Muren JE, Nässel DR. Tachykinin- and leucokinin-related peptides in the nervous system of the blowfly: immunocytochemical and chromatographical diversity. Peptides. 1993 Jul-Aug;14(4):651-63. PubMed PMID: 7694260.

4: Schmid A, Becherer C. Leucokinin-like immunoreactive neurones in the central nervous system of the spider Cupiennius salei. Cell Tissue Res. 1996 Apr;284(1):143-52. PubMed PMID: 8601289.

5: Radford JC, Terhzaz S, Cabrero P, Davies SA, Dow JA. Functional characterisation of the Anopheles leucokinins and their cognate G-protein coupled receptor. J Exp Biol. 2004 Dec;207(Pt 26):4573-86. PubMed PMID: 15579553.

6: Terhzaz S, O'Connell FC, Pollock VP, Kean L, Davies SA, Veenstra JA, Dow JA. Isolation and characterization of a leucokinin-like peptide of Drosophila melanogaster. J Exp Biol. 1999 Dec;202(Pt 24):3667-76. PubMed PMID: 10574744.

7: Elekes K, Hernádi L, Kiss T, Muneoka Y, Nássel DR. Tachykinin- and leucokinin-related peptides in the molluscan nervous system. Acta Biol Hung. 1995;46(2-4):281-94. PubMed PMID: 8853699.

8: Lee BH, Kang H, Kwon D, Park CI, Kim WK, Kim MY. Postembryonic development of leucokinin-like immunoreactive neurons in the moth Spodoptera litura. Tissue Cell. 1998 Feb;30(1):74-85. PubMed PMID: 9569680.

9: Thompson KS, Rayne RC, Gibbon CR, May ST, Patel M, Coast GM, Bacon JP. Cellular colocalization of diuretic peptides in locusts: a potent control mechanism. Peptides. 1995;16(1):95-104. PubMed PMID: 7716080.

10: Smart D, Johnston CF, Shaw C, Halton DW, Buchanan KD. Use of specific antisera for the localisation and quantitation of leucokinin immunoreactivity in the nematode, Ascaris suum. Comp Biochem Physiol C. 1993 Oct;106(2):517-22. PubMed PMID: 7904924.

11: Donini A, O'Donnell MJ, Orchard I. Differential actions of diuretic factors on the Malpighian tubules of Rhodnius prolixus. J Exp Biol. 2008 Jan;211(Pt 1):42-8. PubMed PMID: 18083731.

12: Holman GM, Nachman RJ, Coast GM. Isolation, characterization and biological activity of a diuretic myokinin neuropeptide from the housefly, Musca domestica. Peptides. 1999;20(1):1-10. PubMed PMID: 10098618.

13: Siviter RJ, Nachman RJ, Dani MP, Keen JN, Shirras AD, Isaac RE. Peptidyl dipeptidases (Ance and Acer) of Drosophila melanogaster: major differences in the substrate specificity of two homologs of human angiotensin I-converting enzyme. Peptides. 2002 Nov;23(11):2025-34. PubMed PMID: 12431741.

14: Bijelic G, O'Donnell MJ. Diuretic factors and second messengers stimulate secretion of the organic cation TEA by the Malpighian tubules of Drosophila melanogaster. J Insect Physiol. 2005 Mar;51(3):267-75. PubMed PMID: 15749109.

15: Iaboni A, Holman GM, Nachman RJ, Orchard I, Coast GM. Immunocytochemical localisation and biological activity of diuretic peptides in the housefly, Musca domestica. Cell Tissue Res. 1998 Dec;294(3):549-60. PubMed PMID: 9799471.

16: Veenstra JA, Lau GW, Agricola HJ, Petzel DH. Immunohistological localization of regulatory peptides in the midgut of the female mosquito Aedes aegypti. Histochem Cell Biol. 1995 Nov;104(5):337-47. PubMed PMID: 8574883.

17: Hoshino M, Suzuki E, Miyake T, Sone M, Komatsu A, Nabeshima Y, Hama C. Neural expression of hikaru genki protein during embryonic and larval development of Drosophila melanogaster. Dev Genes Evol. 1999 Jan;209(1):1-9. PubMed PMID: 9914413.

18: Saideman SR, Christie AE, Torfs P, Huybrechts J, Schoofs L, Nusbaum MP. Actions of kinin peptides in the stomatogastric ganglion of the crab Cancer borealis. J Exp Biol. 2006 Sep;209(Pt 18):3664-76. PubMed PMID: 16943506.