WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H598829
CAS#: 119417-96-8
Description: Licoricesaponin E2 is an oleanane-type triterpene oligoglycoside isolated from the air-dried root of Glycyrrhiza uralensis.
Hodoodo Cat#: H598829
Name: Licoricesaponin E2
CAS#: 119417-96-8
Chemical Formula: C42H60O16
Exact Mass: 820.39
Molecular Weight: 820.920
Elemental Analysis: C, 61.45; H, 7.37; O, 31.18
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Synonym: Licoricesaponin E2; Licorice-saponin E2;
IUPAC/Chemical Name: (2S,3S,4S,5R,6R)-6-(((2R,3R,4S,5S,6S)-6-carboxy-2-(((2R,5R,5aR,7aS,7bR,9aR,11R,13aS,13bR,15bS)-2,5a,7a,7b,10,10,13a-heptamethyl-3,14-dioxo-1,2,3,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,13b,14,15b-icosahydro-2,5-methanochryseno[2,1-c]oxepin-11-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
InChi Key: ACCYCJOHUMRMMV-FGXYKJOTSA-N
InChi Code: InChI=1S/C42H60O16/c1-37(2)20-8-11-42(7)31(19(43)14-17-18-15-38(3)16-22(55-36(38)53)39(18,4)12-13-41(17,42)6)40(20,5)10-9-21(37)54-35-30(26(47)25(46)29(57-35)33(51)52)58-34-27(48)23(44)24(45)28(56-34)32(49)50/h14,18,20-31,34-35,44-48H,8-13,15-16H2,1-7H3,(H,49,50)(H,51,52)/t18-,20-,21+,22+,23-,24-,25-,26-,27+,28-,29-,30+,31+,34-,35+,38+,39+,40-,41+,42+/m0/s1
SMILES Code: O[C@@H]([C@@H]([C@@H](C(O)=O)O1)O)[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](C(O)=O)O2)O)O)O)[C@@H]1O[C@@H](C(C)([C@](CC[C@@]([C@@]3(CC[C@]4([C@@](O5)([H])C[C@](C5=O)(C[C@]4(C3=C6)[H])C)C)C)7C)8[H])C)CC[C@]8(C)[C@@]7([H])C6=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 820.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Tao W, Duan J, Guo J, Li J, Tang Y, Liu P, Yang N. Simultaneous determination of triterpenoid saponins in dog plasma by a validated UPLC-MS/MS and its application to a pharmacokinetic study after administration of total saponin of licorice. J Pharm Biomed Anal. 2013 Mar 5;75:248-55. doi: 10.1016/j.jpba.2012.11.035. Epub 2012 Dec 1. PubMed PMID: 23280090.
2: Kitagawa I, Hori K, Uchida E, Chen WZ, Yoshikawa M, Ren J. Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside. Chem Pharm Bull (Tokyo). 1993 Sep;41(9):1567-72. PubMed PMID: 8221970.