E17110

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H555293

CAS#: Unknown

Description: E17110 is a LXRβ agonist. E17110 showed a significant activation effect on LXRβ with an EC50 value of 0.72 μmol/L. E17110 also increased the expression of ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 macrophages. Moreover, E17110 significantly reduced cellular lipid accumulation and promoted cholesterol efflux in RAW264.7 macrophages.

Chemical Structure

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E17110
CAS# Unknown
Instruction

Theoretical Analysis

Hodoodo Cat#: H555293
Name: E17110
CAS#: Unknown
Chemical Formula: C16H15FN2O5
Exact Mass: 334.10
Molecular Weight: 334.303
Elemental Analysis: C, 57.49; H, 4.52; F, 5.68; N, 8.38; O, 23.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: E17110; E-17110; E 17110.

IUPAC/Chemical Name: 1-oxo-1-(2-oxoimidazolidin-1-yl)propan-2-yl 6-fluoro-3-methylbenzofuran-2-carboxylate

InChi Key: SMRPARLQNTVFLB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H15FN2O5/c1-8-11-4-3-10(17)7-12(11)24-13(8)15(21)23-9(2)14(20)19-6-5-18-16(19)22/h3-4,7,9H,5-6H2,1-2H3,(H,18,22)

SMILES Code: FC1=CC=C2C(OC(C(OC(C(N3C(NCC3)=O)=O)C)=O)=C2C)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 334.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Li N, Wang X, Liu P, Lu D, Jiang W, Xu Y, Si S. E17110 promotes reverse
cholesterol transport with liver X receptor β agonist activity in vitro. Acta
Pharm Sin B. 2016 May;6(3):198-204. doi: 10.1016/j.apsb.2016.03.005. Epub 2016
Apr 5. PubMed PMID: 27175330; PubMed Central PMCID: PMC4856951.


2: Pandit B, Gartel AL. Thiazole antibiotic thiostrepton synergize with
bortezomib to induce apoptosis in cancer cells. PLoS One. 2011 Feb
18;6(2):e17110. doi: 10.1371/journal.pone.0017110. PubMed PMID: 21365012; PubMed
Central PMCID: PMC3041825.