UCL-1684 Br
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Hodoodo CAT#: H563563

CAS#: 199934-16-2

Description: UCL-1684 Br is a potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1).

Chemical Structure

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UCL-1684 Br
CAS# 199934-16-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H563563
Name: UCL-1684 Br
CAS#: 199934-16-2
Chemical Formula: C34H30Br2N4
Exact Mass: 652.08
Molecular Weight: 654.450
Elemental Analysis: C, 62.40; H, 4.62; Br, 24.42; N, 8.56

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 600 2 Weeks
25mg USD 950 2 Weeks
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Synonym: UCL-1684 Dibromide; UCL 1684 Dibromide; UCL1684 Dibromide; UCL-1684 Br; UCL 1684 Br; UCL1684 Br;

IUPAC/Chemical Name: 6,10-diaza-1,5(1,4)-diquinolin-1-iuma-3(1,3),8(1,4)-dibenzenacyclodecaphane-11,51-diium bromide

InChi Key: KPNMQIKQVCWNTP-IQRNGZOLSA-N

InChi Code: InChI=1S/C34H28N4.2BrH/c1-3-10-33-29(8-1)31-16-18-37(33)23-27-6-5-7-28(20-27)24-38-19-17-32(30-9-2-4-11-34(30)38)36-22-26-14-12-25(13-15-26)21-35-31;;/h1-20H,21-24H2;2*1H/b35-31-,36-32-;;

SMILES Code: C12=CC=CC=C1C(NCC3=CC=C(C=C3)CNC4=CC=[N+]5C6=C4C=CC=C6)=CC=[N+]2CC7=CC=CC(C5)=C7.[Br-].[Br-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 654.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Abdulkareem ZA, Gee JM, Cox CD, Wann KT. Knockdown of the small conductance Ca(2+) -activated K(+) channels is potently cytotoxic in breast cancer cell lines. Br J Pharmacol. 2016 Jan;173(1):177-90. doi: 10.1111/bph.13357. Epub 2015 Dec 5. PubMed PMID: 26454020; PubMed Central PMCID: PMC4737296.

2: Xu YC, Leung SW, Leung GP, Man RY. Kaempferol enhances endothelium-dependent relaxation in the porcine coronary artery through activation of large-conductance Ca(2+) -activated K(+) channels. Br J Pharmacol. 2015 Jun;172(12):3003-14. doi: 10.1111/bph.13108. Epub 2015 Mar 27. PubMed PMID: 25652142; PubMed Central PMCID: PMC4459019.

3: Feetham CH, Nunn N, Lewis R, Dart C, Barrett-Jolley R. TRPV4 and K(Ca) ion channels functionally couple as osmosensors in the paraventricular nucleus. Br J Pharmacol. 2015 Apr;172(7):1753-68. doi: 10.1111/bph.13023. Epub 2015 Jan 23. PubMed PMID: 25421636; PubMed Central PMCID: PMC4376454.

4: Toniolo EF, Maique ET, Ferreira WA Jr, Heimann AS, Ferro ES, Ramos-Ortolaza DL, Miller L, Devi LA, Dale CS. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31. doi: 10.1016/j.peptides.2014.03.016. Epub 2014 Apr 3. PubMed PMID: 24703998; PubMed Central PMCID: PMC4112957.

5: Chennupati R, Lamers WH, Koehler SE, De Mey JG. Endothelium-dependent hyperpolarization-related relaxations diminish with age in murine saphenous arteries of both sexes. Br J Pharmacol. 2013 Aug;169(7):1486-99. doi: 10.1111/bph.12175. PubMed PMID: 23488619; PubMed Central PMCID: PMC3724106.

6: Chubanov V, Mederos y Schnitzler M, Meißner M, Schäfer S, Abstiens K, Hofmann T, Gudermann T. Natural and synthetic modulators of SK (K(ca)2) potassium channels inhibit magnesium-dependent activity of the kinase-coupled cation channel TRPM7. Br J Pharmacol. 2012 Jun;166(4):1357-76. doi: 10.1111/j.1476-5381.2012.01855.x. PubMed PMID: 22242975; PubMed Central PMCID: PMC3417452.

7: Schmidt K, Dubrovska G, Nielsen G, Fesüs G, Uhrenholt TR, Hansen PB, Gudermann T, Dietrich A, Gollasch M, de Wit C, Köhler R. Amplification of EDHF-type vasodilatations in TRPC1-deficient mice. Br J Pharmacol. 2010 Dec;161(8):1722-33. doi: 10.1111/j.1476-5381.2010.00985.x. PubMed PMID: 20718731; PubMed Central PMCID: PMC3010578.

8: Sones WR, Leblanc N, Greenwood IA. Inhibition of vascular calcium-gated chloride currents by blockers of KCa1.1, but not by modulators of KCa2.1 or KCa2.3 channels. Br J Pharmacol. 2009 Sep;158(2):521-31. doi: 10.1111/j.1476-5381.2009.00332.x. Epub 2009 Jul 23. PubMed PMID: 19645713; PubMed Central PMCID: PMC2757692.

9: Michel FS, Man GS, Man RY, Vanhoutte PM. Hypertension and the absence of EDHF-mediated responses favour endothelium-dependent contractions in renal arteries of the rat. Br J Pharmacol. 2008 Sep;155(2):217-26. doi: 10.1038/bjp.2008.256. Epub 2008 Jun 23. PubMed PMID: 18574459; PubMed Central PMCID: PMC2538696.

10: Gluais P, Edwards G, Weston AH, Falck JR, Vanhoutte PM, Félétou M. Role of SK(Ca) and IK(Ca) in endothelium-dependent hyperpolarizations of the guinea-pig isolated carotid artery. Br J Pharmacol. 2005 Feb;144(4):477-85. PubMed PMID: 15655533; PubMed Central PMCID: PMC1576024.

11: Andersson DA, Zygmunt PM, Movahed P, Andersson TL, Högestätt ED. Effects of inhibitors of small- and intermediate-conductance calcium-activated potassium channels, inwardly-rectifying potassium channels and Na(+)/K(+) ATPase on EDHF relaxations in the rat hepatic artery. Br J Pharmacol. 2000 Apr;129(7):1490-6. PubMed PMID: 10742306; PubMed Central PMCID: PMC1571979.

12: Malik-Hall M, Ganellin CR, Galanakis D, Jenkinson DH. Compounds that block both intermediate-conductance (IK(Ca)) and small-conductance (SK(Ca)) calcium-activated potassium channels. Br J Pharmacol. 2000 Apr;129(7):1431-8. PubMed PMID: 10742299; PubMed Central PMCID: PMC1571984.

13: Strøbaek D, Jørgensen TD, Christophersen P, Ahring PK, Olesen SP. Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells. Br J Pharmacol. 2000 Mar;129(5):991-9. PubMed PMID: 10696100; PubMed Central PMCID: PMC1571906.