WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H598960
CAS#: 68890-65-3
Description: Lipofundin S is an emulsion containing soy bean oil, soy phosphatides & glycerol.
Hodoodo Cat#: H598960
Name: Lipofundin S
CAS#: 68890-65-3
Chemical Formula: C60H115NO10P
Exact Mass: 0.00
Molecular Weight: 1,041.543
Elemental Analysis: C, 69.19; H, 11.13; N, 1.34; O, 15.36; P, 2.97
Synonym: Lipofundin S; Lipofundin S 10; Intralipid 20; Intralipid; Medialipid; Phospholipid - stabilized soybean oil; Salvilipid; Travamulsion;
IUPAC/Chemical Name: (9Z,12Z)-octadeca-9,12-dienoic acid, (E)-2-((hydroxy(2-(octadec-9-enoyloxy)-3-(palmitoyloxy)propoxy)phosphoryl)oxy)-N,N,N-trimethylethan-1-aminium salt
InChi Key: ZACMUBKIFQNSDT-GAUHYDFOSA-O
InChi Code: InChI=1S/C42H82NO8P.C18H32O2/c1-6-8-10-12-14-16-18-20-21-23-25-27-29-31-33-35-42(45)51-40(39-50-52(46,47)49-37-36-43(3,4)5)38-48-41(44)34-32-30-28-26-24-22-19-17-15-13-11-9-7-2;1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h20-21,40H,6-19,22-39H2,1-5H3;6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/p+1/b21-20+;7-6-,10-9-
SMILES Code: CCCCCCCCCCCCCCCC(OCC(OC(CCCCCCC/C=C/CCCCCCCC)=O)COP(O)(OCC[N+](C)(C)C)=O)=O.CCCCC/C=C\C/C=C\CCCCCCCC(O)=O
Appearance: Liquid
Purity: 20%, emulsion
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 1,041.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Vidovanets IuM, Nikula IP. [Lipofundin S in the treatment of radiation cystitis]. Med Radiol (Mosk). 1990 Jun;35(6):31. Russian. PubMed PMID: 2355808.
2: Leonhardt W, Julius U, Schulze J, Hanefeld M, Haller H. Elimination of lipofundin S during the intravenous fat tolerance test in patients with low, medium, and high fasting triglyceride concentrations. JPEN J Parenter Enteral Nutr. 1985 Jul-Aug;9(4):461-3. PubMed PMID: 4032683.
3: Leonhardt W, Julius U. [Intraindividual comparison of the elimination kinetics of Lipofundin S and Intralipid in consecutive lipid tolerance tests]. Infusionstherapie. 1988 Aug;15(4):159-62. German. PubMed PMID: 3182098.
4: Di Ninni P, Bérubé-Lauzière Y, Mercatelli L, Sani E, Martelli F. Fat emulsions as diffusive reference standards for tissue simulating phantoms? Appl Opt. 2012 Oct 20;51(30):7176-82. doi: 10.1364/AO.51.007176. PubMed PMID: 23089769.
5: Saladino CF, Yeh Q, Zimmer E, Jonas EA. The effect of atherogenic infusions of the triglyceride-rich, lipid emulsion, Lipofundin-S, on the in vitro growth characteristics of rat aortic smooth muscle cells. Artery. 1992;19(2):76-93. PubMed PMID: 1580799.
6: Andersen HL, Nissen I. [Presumed anaphylactic shock after infusion of Lipofundin]. Ugeskr Laeger. 1993 Jul 12;155(28):2210-1. Danish. PubMed PMID: 8328083.
7: Förster H. [Differences in the elimination of intravenously administered intralipid and lipofundin S]. Infusionsther Klin Ernahr. 1981 Feb;8(1):50-2. German. PubMed PMID: 6783527.
8: Harsing J, Füzesi S. [A new model for arteriosclerosis. Electron microscopic study of the reaction of the arterial wall following lipofundin-S administration]. Morphol Igazsagugyi Orv Sz. 1981 Jul;21(3):168-73. Hungarian. PubMed PMID: 7266550.
9: Kozyr' VI, Pindrikov LL, Dziubko NP. [Acute renal failure after infusion of lipofundin S]. Klin Med (Mosk). 1984 Apr;62(4):130-2. Russian. PubMed PMID: 6737961.
10: Julius U, Leonhardt W. Elimination and metabolism of a fat emulsion containing medium chain triglycerides (lipofundin MCT 10%). JPEN J Parenter Enteral Nutr. 1988 Mar-Apr;12(2):116-20. PubMed PMID: 3361679.
11: Takacs E, Jellinek H. Lymphatics in the aorta of rats treated with a soy-bean oil extract (lipofundin). Lymphology. 1986 Dec;19(4):161-7. PubMed PMID: 3561036.
12: Stepanov SA, Iusupova IU, Grozdov SP. [Changes in lipid metabolism in rats with radiation sickness and a pronounced intestinal syndrome during parenteral feeding with lipofundin and infusolipol]. Radiobiologiia. 1988 Nov-Dec;28(6):775-9. Russian. PubMed PMID: 3146104.
13: Hailer S, Wolfram G, Zöllner N. Changes in serum lipoproteins in humans following the infusion of a fat emulsion containing medium- and long-chain triglycerides. Eur J Clin Invest. 1987 Oct;17(5):402-7. PubMed PMID: 3121343.
14: Förster H, Quadbeck R, Anschütz A. [The problem of dosage and importance of fats in parenteral feeding]. Infusionsther Klin Ernahr. 1979 Dec;6(6):362-8. German. PubMed PMID: 120326.
15: Takács E, Jellinek H. [Lymphatic vessels in the aorta of lipofundin-treated rats]. Morphol Igazsagugyi Orv Sz. 1986 Apr;26(2):107-13. Hungarian. PubMed PMID: 3713710.
16: Saladino CF, Klein RA, Jonas EA. Induction of early atherosclerosis in rats using parenterally-administered lipid emulsions. Artery. 1987;14(5):304-15. PubMed PMID: 3662845.
17: Takács E, Hársing J, Füzesi S, Jellinek H. [Arteriosclerosis developing in rabbits after lipofundin administration]. Morphol Igazsagugyi Orv Sz. 1986 Apr;26(2):99-105. Hungarian. PubMed PMID: 3713717.
18: Hársing J, Takács E, Füzesi S, Jellinek H. [Recent studies on a lipofundin-induced arteriosclerosis model]. Morphol Igazsagugyi Orv Sz. 1986 Apr;26(2):89-98. Hungarian. PubMed PMID: 3713716.
19: Mangano M, Colombo P, Bianchi PA, Penagini R. Fat and esophageal sensitivity to acid. Dig Dis Sci. 2002 Mar;47(3):657-60. PubMed PMID: 11911356.
20: Ball MJ. Hematological and biochemical effects of parenteral nutrition with medium-chain triglycerides: comparison with long-chain triglycerides. Am J Clin Nutr. 1991 Apr;53(4):916-22. PubMed PMID: 1901194.