S 11568

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H461606

CAS#: 132636-01-2

Description: S 11568 is a dihydropyridine calcium channel antagonist.

Chemical Structure

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S 11568
CAS# 132636-01-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H461606
Name: S 11568
CAS#: 132636-01-2
Chemical Formula: C22H29Cl3N2O6
Exact Mass: 522.11
Molecular Weight: 523.830
Elemental Analysis: C, 50.44; H, 5.58; Cl, 20.30; N, 5.35; O, 18.33

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: S 11568; S-11568; S11568; S 12968; S-12968; S12968;

IUPAC/Chemical Name: 3-ethyl 5-methyl 2-((2-(2-aminoethoxy)ethoxy)methyl)-4-(2,3-dichlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate hydrochloride

InChi Key: CHEDLCOJOZRZRL-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H28Cl2N2O6.ClH/c1-4-32-22(28)19-16(12-31-11-10-30-9-8-25)26-13(2)17(21(27)29-3)18(19)14-6-5-7-15(23)20(14)24;/h5-7,18,26H,4,8-12,25H2,1-3H3;1H

SMILES Code: O=C(C1=C(COCCOCCN)NC(C)=C(C(OC)=O)C1C2=CC=CC(Cl)=C2Cl)OCC.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 523.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Valette H, Dollé F, Guenther I, Hinnen F, Fuseau C, Coulon C, Péglion JL, Crouzel C. Myocardial kinetics of the (11)C-labeled enantiomers of the Ca(2+) channel inhibitor S11568: an in vivo study. J Nucl Med. 2001 Jun;42(6):932-7. PubMed PMID: 11390559.

2: Dollé F, Valette H, Hinnen F, Fuseau C, Péglion JL, Crouzel C. Synthesis and characterization of a 11C-labelled derivative of S12968: an attempt to image in vivo brain calcium channels. Nucl Med Biol. 1998 May;25(4):339-42. PubMed PMID: 9639294.

3: Dollé F, Hinnen F, Valette H, Fuseau C, Duval R, Péglion JL, Crouzel C. Synthesis of two optically active calcium channel antagonists labelled with carbon-11 for in vivo cardiac PET imaging. Bioorg Med Chem. 1997 Apr;5(4):749-64. PubMed PMID: 9158874.

4: Valette H, Crouzel C, Syrota A, Fuseau C, Bourachot ML. Canine myocardial dihydropyridine binding sites: a positron emission tomographic study with the calcium channel inhibitor 11C-S11568. Life Sci. 1994;55(19):1471-7. PubMed PMID: 7968214.

5: Morain P, Peglion JL, Giesen-Crouse E. Ca2+ channel inhibition in a rat osteoblast-like cell line, UMR 106, by a new dihydropyridine derivative, S11568. Eur J Pharmacol. 1992 Sep 10;220(1):11-7. PubMed PMID: 1385178.

6: Makki T, Lartaud I, Bray-des Boscs L, Capdeville-Atkinson C, Chillon JM, Hoffman M, Nicolas JP, Atkinson J. Haemodynamic effects of a new dihydropyridine calcium entry blocker, S-12968-(-), in a rat model of cardiovascular calcium overload. Br J Pharmacol. 1992 May;106(1):79-84. PubMed PMID: 1324069; PubMed Central PMCID: PMC1907437.

7: Vilaine JP, Biondi ML, Villeneuve N, Feletou M, Peglion JL, Vanhoutte PM. The calcium channel antagonist S 11568 causes endothelium-dependent relaxation in canine arteries. Eur J Pharmacol. 1991 May 2;197(1):41-8. PubMed PMID: 1654260.

8: Randle JC, Péglion JL, Renaud JF. Inhibition of L-type but not T-type calcium channel current by a new dihydropyridine derivative, S11568. J Cardiovasc Pharmacol. 1991 Feb;17(2):348-50. PubMed PMID: 1709243.

9: Randle JC, Lombet A, Nagel N, Abraham C, Aptel H, Peglion JL, Renaud JF. Ca2+ channel inhibition by a new dihydropyridine derivative, S11568, and its enantiomers S12967 and S12968. Eur J Pharmacol. 1990 Nov 6;190(1-2):85-96. PubMed PMID: 1706275.