WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H592793
CAS#: 62265-68-3
Description: Quinfamide is used in the treatment of chronic amebiasis in pediatric patients.
Hodoodo Cat#: H592793
Name: Quinfamide
CAS#: 62265-68-3
Chemical Formula: C16H13Cl2NO4
Exact Mass: 353.02
Molecular Weight: 354.180
Elemental Analysis: C, 54.26; H, 3.70; Cl, 20.02; N, 3.95; O, 18.07
This product is not in stock, which may be available by custom synthesis.
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Synonym: Quinfamide; Quinfamido
IUPAC/Chemical Name: 2-Furancarboxylic acid, 1-(dichloroacetyl)-1,2,3,4-tetrahydro-6-quinolinyl ester
InChi Key: SBJGFIXQRZOVTO-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13Cl2NO4/c17-14(18)15(20)19-7-1-3-10-9-11(5-6-12(10)19)23-16(21)13-4-2-8-22-13/h2,4-6,8-9,14H,1,3,7H2
SMILES Code: O=C(C1=CC=CO1)OC2=CC3=C(N(C(C(Cl)Cl)=O)CCC3)C=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 354.18 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Naguib IA, Hassan ES, Emam AA, Abdelaleem EA. Development and Validation of HPTLC and Green HPLC Methods for Determination of a New Combination of Quinfamide and Mebendazole. J Chromatogr Sci. 2019 Dec 19;58(1):16-21. doi:10.1093/chromsci/bmz100. PMID: 31879753.
2. Cedillo-Rivera R, Muñoz O. In-vitro susceptibility of Giardia lamblia to albendazole, mebendazole and other chemotherapeutic agents. J Med Microbiol. 1992 Sep;37(3):221-4. doi: 10.1099/00222615-37-3-221. PMID: 1518040.
3. Padilla N, Diaz R, Alarcon A, Barreda R. Antiamoebic chemoprophylaxis using quinfamide in children: a comparative study. ScientificWorldJournal. 2002 Apr 20;2:1070-8. doi: 10.1100/tsw.2002.174. PMID: 12805964; PMCID: PMC6009339.
4. Padilla N, Díaz R, Muñoz M. Efficacy and Safety of Quinfamide versus Secnidazole in the Management of Amoebic NonDysenteric Colitis in Children. Clin Drug Investig. 2000;20(2):89-93. doi: 10.2165/00044011-200020020-00003. PMID:
23315350.