G10 STING agonist
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Hodoodo CAT#: H563675

CAS#: 702662-50-8

Description: G10 is a human-specific STING agonist, triggering IRF3/IFN-associated transcription in human fibroblasts.

Chemical Structure

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G10 STING agonist
CAS# 702662-50-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H563675
Name: G10 STING agonist
CAS#: 702662-50-8
Chemical Formula: C21H16ClFN2O3S
Exact Mass: 430.06
Molecular Weight: 430.870
Elemental Analysis: C, 58.54; H, 3.74; Cl, 8.23; F, 4.41; N, 6.50; O, 11.14; S, 7.44

Price and Availability

Size Price Availability Quantity
100mg USD 850 2 Weeks
200mg USD 1450 2 Weeks
500mg USD 2250 2 Weeks
1g USD 3250 2 Weeks
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Synonym: G10; G-10; G 10; STING agonist G10;

IUPAC/Chemical Name: 4-(2-Chloro-6-fluorobenzyl)-N-(furan-2-ylmethyl)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide

InChi Key: NAGKYJATVFXZKN-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H16ClFN2O3S/c22-16-4-1-5-17(23)15(16)11-25-18-9-13(6-7-19(18)29-12-20(25)26)21(27)24-10-14-3-2-8-28-14/h1-9H,10-12H2,(H,24,27)

SMILES Code: O=C(C1=CC=C(C(N2CC3=C(F)C=CC=C3Cl)=C1)SCC2=O)NCC4=CC=CO4

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 430.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sali TM, Pryke KM, Abraham J, Liu A, Archer I, Broeckel R, Staverosky JA, Smith JL, Al-Shammari A, Amsler L, Sheridan K, Nilsen A, Streblow DN, DeFilippis VR. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324. doi: 10.1371/journal.ppat.1005324. eCollection 2015 Dec. PubMed PMID: 26646986; PubMed Central PMCID: PMC4672893.