Arteflene

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H592967

CAS#: 123407-36-3

Description: Arteflene is an Anti-malarial drug.

Chemical Structure

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Arteflene
CAS# 123407-36-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H592967
Name: Arteflene
CAS#: 123407-36-3
Chemical Formula: C19H18F6O3
Exact Mass: 408.12
Molecular Weight: 408.340
Elemental Analysis: C, 55.89; H, 4.44; F, 27.92; O, 11.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Arteflene

IUPAC/Chemical Name: 2,3-Dioxabicyclo(3.3.1)nonan-7-one, 4-(2-(2,4-bis(trifluoromethyl)phenyl)ethenyl)-4,8-dimethyl-(1S-(1alpha,4beta(Z),5alpha,8beta))-

InChi Key: LRTRTVPZZJAADL-DAHZFVMQSA-N

InChi Code: InChI=1S/C19H18F6O3/c1-10-15(26)8-13-9-16(10)27-28-17(13,2)6-5-11-3-4-12(18(20,21)22)7-14(11)19(23,24)25/h3-7,10,13,16H,8-9H2,1-2H3/b6-5-/t10-,13+,16+,17+/m1/s1

SMILES Code: O=C1C[C@]2([H])[C@](C)(/C=C\C3=CC=C(C(F)(F)F)C=C3C(F)(F)F)OO[C@](C2)([H])[C@@H]1C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 408.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Maggs JL, Bishop LP, Batty KT, Dodd CC, Ilett KF, O'Neill PM, Edwards G, Kevin Park B. Hepatocellular bioactivation and cytotoxicity of the synthetic endoperoxide antimalarial arteflene. Chem Biol Interact. 2004 Mar 15;147(2):173-84. PubMed PMID: 15013819.

2: Cazelles J, Robert A, Meunier B. Characterization of the Main Radical and Products Resulting from a Reductive Activation of the Antimalarial Arteflene (Ro 42-1611). J Org Chem. 1999 Sep 3;64(18):6776-6781. PubMed PMID: 11674686.

3: Bishop LP, Maggs JL, O'Neill PM, Park BK. Metabolism of the antimalarial endoperoxide Ro 42-1611 (arteflene) in the rat: evidence for endoperoxide bioactivation. J Pharmacol Exp Ther. 1999 Apr;289(1):511-20. PubMed PMID: 10087044.

4: Radloff PD, Philipps J, Nkeyi M, Sturchler D, Mittelholzer ML, Kremsner PG. Arteflene compared with mefloquine for treating Plasmodium falciparum malaria in children. Am J Trop Med Hyg. 1996 Sep;55(3):259-62. PubMed PMID: 8842111.

5: Jakobsen PH, Staalsø T, Bendtzen K, Stürchler D. The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites. Trop Med Parasitol. 1995 Jun;46(2):88-92. PubMed PMID: 8525291.

6: Somo-Moyou R, Mittelholzer ML, Sorenson F, Haller L, Stürchler D. Efficacy of Ro 42-1611 (arteflene) in the treatment of patients with mild malaria: a clinical trial in Cameroon. Trop Med Parasitol. 1994 Sep;45(3):288-91. PubMed PMID: 7899806.

7: Weidekamm E, Dumont E, Jaquet C. Tolerability and pharmacokinetics of Ro 42-1611 (arteflene) in man. Trop Med Parasitol. 1994 Sep;45(3):278-83. PubMed PMID: 7899804.

8: Girometta MA, Jauch R, Ponelle C, Guenzi A, Wiegand-Chou RC. Animal pharmacokinetics and metabolism of the new antimalarial Ro 42-1611 (arteflene). Trop Med Parasitol. 1994 Sep;45(3):272-7. PubMed PMID: 7899803.

9: Jaquet C, Stohler HR, Chollet J, Peters W. Antimalarial activity of the bicyclic peroxide Ro 42-1611 (arteflene) in experimental models. Trop Med Parasitol. 1994 Sep;45(3):266-71. PubMed PMID: 7899802.