ABC44
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Hodoodo CAT#: H563742

CAS#: 1831135-46-6

Description: ABC44 is a potent and selective inhibitor of palmitoyl-protein thioesterase 1 (PPT-1) with notably more activity in situ than in vitro. ABC44 showed potent, dose-dependent inhibition of an ABC45-reactive protein matching the molecular mass of deglycosylated PPT1 in PNGaseF-treated central and peripheral tissues, producing near-complete blockade of this enzyme activity at 1–5 mg/kg. ABC44 showed excellent selectivity for PPT1 and did not inhibit other SHs detected in brain and testis tissues treated with the FP-Rh or ABC45 probes.


Chemical Structure

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ABC44
CAS# 1831135-46-6

Theoretical Analysis

Hodoodo Cat#: H563742
Name: ABC44
CAS#: 1831135-46-6
Chemical Formula: C31H40N6O5
Exact Mass: 576.31
Molecular Weight: 576.690
Elemental Analysis: C, 64.56; H, 6.99; N, 14.57; O, 13.87

Price and Availability

Size Price Availability Quantity
5mg USD 260 2 Weeks
25mg USD 660 2 Weeks
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Synonym: ABC44; ABC-44; ABC 44;

IUPAC/Chemical Name: 7-((1-Benzylpiperidin-4-yl)methyl)-1,3-dioxohexahydroimidazo[1,5-a]pyrazin-2(3H)-yl 4-(4-methoxyphenyl)piperazine-1-carboxylate

InChi Key: YHRQLTHMALGXOG-UHFFFAOYSA-N

InChi Code: InChI=1S/C31H40N6O5/c1-41-27-9-7-26(8-10-27)34-16-18-35(19-17-34)31(40)42-37-29(38)28-23-33(15-20-36(28)30(37)39)22-25-11-13-32(14-12-25)21-24-5-3-2-4-6-24/h2-10,25,28H,11-23H2,1H3

SMILES Code: O=C(N1CCN(C2=CC=C(OC)C=C2)CC1)ON(C3=O)C(N4C3CN(CC5CCN(CC6=CC=CC=C6)CC5)CC4)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 576.69 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cognetta AB 3rd, Niphakis MJ, Lee HC, Martini ML, Hulce JJ, Cravatt BF. Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases. Chem Biol. 2015 Jul 23;22(7):928-37. doi: 10.1016/j.chembiol.2015.05.018. Epub 2015 Jun 25. PMID: 26120000; PMCID: PMC4527528.