WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555320
CAS#: 1375557-33-7
Description: A-1293201 is a potent and selective NAMPT inhibitor.
Hodoodo Cat#: H555320
Name: A-1293201
CAS#: 1375557-33-7
Chemical Formula: C21H23N3O3
Exact Mass: 365.17
Molecular Weight: 365.433
Elemental Analysis: C, 69.02; H, 6.34; N, 11.50; O, 13.13
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Synonym: A-1293201; A 1293201; A1293201;
IUPAC/Chemical Name: (S)-N-(4-(((tetrahydrofuran-3-yl)methyl)carbamoyl)phenyl)isoindoline-2-carboxamide
InChi Key: BLZJCPAXCWJANZ-HNNXBMFYSA-N
InChi Code: InChI=1S/C21H23N3O3/c25-20(22-11-15-9-10-27-14-15)16-5-7-19(8-6-16)23-21(26)24-12-17-3-1-2-4-18(17)13-24/h1-8,15H,9-14H2,(H,22,25)(H,23,26)/t15-/m0/s1
SMILES Code: O=C(N1CC2=C(C=CC=C2)C1)NC3=CC=C(C(NC[C@H]4COCC4)=O)C=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 365.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Guo J, Lam LT, Longenecker KL, Bui MH, Idler KB, Glaser KB, Wilsbacher JL, Tse
C, Pappano WN, Huang TH. Identification of novel resistance mechanisms to NAMPT
inhibition via the de novo NAD(+) biosynthesis pathway and NAMPT mutation.
Biochem Biophys Res Commun. 2017 Sep 23;491(3):681-686. doi:
10.1016/j.bbrc.2017.07.143. Epub 2017 Jul 26. PubMed PMID: 28756225.