JAK3 Inhibitor VI
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H564205

CAS#: 856436-16-3

Description: JAK3 Inhibitor VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3).

Chemical Structure

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JAK3 Inhibitor VI
CAS# 856436-16-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H564205
Name: JAK3 Inhibitor VI
CAS#: 856436-16-3
Chemical Formula: C19H17N3O4S
Exact Mass: 383.09
Molecular Weight: 383.420
Elemental Analysis: C, 59.52; H, 4.47; N, 10.96; O, 16.69; S, 8.36

Price and Availability

Size Price Availability Quantity
5mg USD 415 2 Weeks
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Synonym: JAK3 Inhibitor VI; JAK-3 Inhibitor VI; JAK 3 Inhibitor VI

IUPAC/Chemical Name: (Z)-3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one Mesylate

InChi Key: ZUDPNBZMAJGYTE-HYMQDMCPSA-N

InChi Code: InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-;

SMILES Code: O=C1NC2=C(C=C(C3=CC=CN=C3)C=C2)/C1=C/C4=CC=CN4.OS(=O)(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 383.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nishiya N, Sakamoto Y, Oku Y, Nonaka T, Uehara Y. JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. World J Biol Chem. 2015 Nov 26;6(4):409-18. doi: 10.4331/wjbc.v6.i4.409. PubMed PMID: 26629323; PubMed Central PMCID: PMC4657120.