WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555347
CAS#: 2271358-65-5 (HCl)
Description: UAMC-3203 is a Ferroptosis Inhibitor wtih IC50 = 12 nM. UAMC-3203 showed an improved protection compared to Fer-1 against multiorgan injury in mice. No toxicity was observed in mice after daily injection of UAMC-3203 for 4 weeks. UAMC-3203 inserts rapidly in a phospholipid bilayer in silico, which aligns with the current understanding of the mechanism of action of these compounds. In conclusion, these analogues have superior properties compared to Fer-1, show in vivo efficacy, and represent novel lead compounds with therapeutic potential in relevant ferroptosis-driven disease models.
Hodoodo Cat#: H555347
Name: UAMC-3203 HCl
CAS#: 2271358-65-5 (HCl)
Chemical Formula: C25H38ClN5O2S
Exact Mass: 0.00
Molecular Weight: 508.122
Elemental Analysis: C, 59.10; H, 7.54; Cl, 6.98; N, 13.78; O, 6.30; S, 6.31
Related CAS #: 2271358-65-5 (HCl) 2271358-64-4 (free base)
Synonym: UAMC-3203 HCl; UAMC-3203 hydrochloride; UAMC-3203; UAMC 3203; UAMC3203;
IUPAC/Chemical Name: 3-(Benzylamino)-4-(cyclohexylamino)-N-(2-(piperazin-1-yl)-ethyl)benzenesulfonamide Hydrochloride
InChi Key: WBZHHIZXEXJBSM-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H37N5O2S.ClH/c31-33(32,28-15-18-30-16-13-26-14-17-30)23-11-12-24(29-22-9-5-2-6-10-22)25(19-23)27-20-21-7-3-1-4-8-21;/h1,3-4,7-8,11-12,19,22,26-29H,2,5-6,9-10,13-18,20H2;1H
SMILES Code: O=S(C1=CC=C(NC2CCCCC2)C(NCC3=CC=CC=C3)=C1)(NCCN4CCNCC4)=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info: Ferroptosis is an iron-catalyzed, nonapoptotic form of regulated necrosis that results in oxidative lipid damage in cell membranes that can be inhibited by the radical-trapping antioxidant Ferrostatin-1 (Fer-1).
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The following data is based on the product molecular weight 508.12 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
Discovery of Novel, Drug-Like Ferroptosis Inhibitors with in Vivo Efficacy
Lars Devisscher, Samya Van Coillie, Sam Hofmans, Dries Van Rompaey, Kenneth Goossens, Eline Meul, Louis Maes, Hans De Winter, Pieter Van Der Veken, Peter Vandenabeele, Tom Vanden Berghe, and Koen Augustyns
Publication Date (Web): October 25, 2018 (Article)
DOI: 10.1021/acs.jmedchem.8b01299