W2476

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H564429

CAS#: 432016-77-8 (free base)

Description: W2476 is a modulator of the thioredoxin-interacting protein signaling pathway, which ameliorates ß-cell dysfunction and exerts therapeutic effects in mouse models of diabetes.

Chemical Structure

img
W2476
CAS# 432016-77-8 (free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H564429
Name: W2476
CAS#: 432016-77-8 (free base)
Chemical Formula: C15H15N5O2
Exact Mass: 297.12
Molecular Weight: 297.320
Elemental Analysis: C, 60.60; H, 5.09; N, 23.56; O, 10.76

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 432016-77-8 (free base)   1217067-40-7 (HCl)    

Synonym: W-2476; W 2476; W2476

IUPAC/Chemical Name: 1-(4-(2-(6-amino-9H-purin-9-yl)ethoxy)phenyl)ethan-1-one

InChi Key: ONZGILNKQYWMNI-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H15N5O2/c1-10(21)11-2-4-12(5-3-11)22-7-6-20-9-19-13-14(16)17-8-18-15(13)20/h2-5,8-9H,6-7H2,1H3,(H2,16,17,18)

SMILES Code: CC(C1=CC=C(OCCN2C=NC3=C(N)N=CN=C23)C=C1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Li T, Lin GY, Zhong L, Zhou Y, Wang J, Zhu Y, Feng Y, Cai XQ, Liu Q, Nosjean O, Boutin JA, Renard P, Yang DH, Wang MW. W2476 ameliorates β-cell dysfunction and exerts therapeutic effects in mouse models of diabetes via modulation of the thioredoxin-interacting protein signaling pathway. Acta Pharmacol Sin. 2017 Jul;38(7):1024-1037. doi: 10.1038/aps.2017.15. Epub 2017 May 15. PubMed PMID: 28502980; PubMed Central PMCID: PMC5519249.

2: Zhong L, Liu Q, Ting YS, Thien VY, Binti Kalong NS, Yang D, Wang MW. Adenine derivatives invert high glucose-induced thioredoxin-interacting protein overexpression. Chem Biol Drug Des. 2018 Jul 25. doi: 10.1111/cbdd.13371. [Epub ahead of print] PubMed PMID: 30043441.