WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555368
CAS#: 281224-40-6
Description: M-31850 is a β-Hexosaminidase Inhibitor. M-31850 showed activity against the insect β-N-acetyl-D-hexosaminidase OfHex2. M-31850 acts as a substrate-competitive and selective inhibitor against human β-N-acetyl hexosaminidase (IC50 = 6.0 & 3.1 µM for hHex A & hHex B, respectively), while exhibiting much reduced potency against Jack Bean or bacterial Hex (IC50 = 280 & >500 µM for JBHex & SpHex, respectively) and little or no activity against SmHex or hOGN.
Hodoodo Cat#: H555368
Name: M-31850
CAS#: 281224-40-6
Chemical Formula: C28H21N3O4
Exact Mass: 463.15
Molecular Weight: 463.493
Elemental Analysis: C, 72.56; H, 4.57; N, 9.07; O, 13.81
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Synonym: M-31850; M 31850; M31850;
IUPAC/Chemical Name: 2,2'-(azanediylbis(ethane-2,1-diyl))bis(1H-benzo[de]isoquinoline-1,3(2H)-dione)
InChi Key: UPLUIYHKSADQOZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C28H21N3O4/c32-25-19-9-1-5-17-6-2-10-20(23(17)19)26(33)30(25)15-13-29-14-16-31-27(34)21-11-3-7-18-8-4-12-22(24(18)21)28(31)35/h1-12,29H,13-16H2
SMILES Code: O=C(C1=CC=CC2=C1C3=CC=C2)N(CCNCCN(C4=O)C(C5=CC=CC6=C5C4=CC=C6)=O)C3=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: The GH20 β-N-acetyl-d-hexosaminidase OfHex2 from the insect Ostrinia furnacalis (Guenée) is a target potential for eco-friendly pesticide development. Although carbohydrate-based inhibitors against β-N-acetyl-D-hexosaminidases are widely studied, highly efficient, non-carbohydrate inhibitors are more attractive due to low cost and readily synthetic manner.
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 463.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Liu T, Guo P, Zhou Y, Wang J, Chen L, Yang H, Qian X, Yang Q. A crystal
structure-guided rational design switching non-carbohydrate inhibitors'
specificity between two β-GlcNAcase homologs. Sci Rep. 2014 Aug 26;4:6188. doi:
10.1038/srep06188. PubMed PMID: 25155420; PubMed Central PMCID: PMC4143770.
2: Chen Q, Guo P, Xu L, Liu T, Qian X, Yang Q. Exploring unsymmetrical dyads as
efficient inhibitors against the insect β-N-acetyl-D-hexosaminidase OfHex2.
Biochimie. 2014 Feb;97:152-62. doi: 10.1016/j.biochi.2013.10.008. Epub 2013 Oct
17. PubMed PMID: 24140956.
