Withanolide B
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Hodoodo CAT#: H530264

CAS#: 56973-41-2

Description: Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B was identified as a neuronal nitric oxide synthase (nNOS) inhibitor that also inhibited inducible NOS (iNOS) and endothelial NOS and as a ligand for the PARP1 catalytic domain.

Chemical Structure

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Withanolide B
CAS# 56973-41-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H530264
Name: Withanolide B
CAS#: 56973-41-2
Chemical Formula: C28H38O5
Exact Mass: 454.27
Molecular Weight: 454.607
Elemental Analysis: C, 73.98; H, 8.43; O, 17.60

Price and Availability

Size Price Availability Quantity
1mg USD 240
5mg USD 530
10mg USD 805
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Synonym: Withanolide B

IUPAC/Chemical Name: (5alpha,6alpha,7alpha,22R)-5-Hydroxy-6,7:22,26-diepoxyergosta-2,24-diene-1,26-dione

InChi Key: ZTEVDTFJUUJBLP-HGSBMKTESA-N

InChi Code: InChI=1S/C28H38O5/c1-14-13-20(32-25(30)15(14)2)16(3)17-8-9-18-22-19(10-12-26(17,18)4)27(5)21(29)7-6-11-28(27,31)24-23(22)33-24/h6-7,16-20,22-24,31H,8-13H2,1-5H3/t16-,17+,18-,19-,20+,22-,23+,24+,26+,27-,28-/m0/s1

SMILES Code: CC(C[C@@H](O1)[C@@H](C)[C@H]([C@]2(CC[C@]3([H])[C@@]45C)C)CC[C@@]2([H])[C@]3([H])[C@]6([H])[C@](O6)([H])[C@@]5(O)CC=CC4=O)=C(C)C1=O

Appearance: Solid powder

Purity: >95% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 454.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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