WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584751
CAS#: 148504-23-8
Description: P 34081 rapidly blocks parasite cysteine proteinase activity in vivo.
Hodoodo Cat#: H584751
Name: P 34081
CAS#: 148504-23-8
Chemical Formula: C26H33FN4O4
Exact Mass: 484.25
Molecular Weight: 484.572
Elemental Analysis: C, 64.45; H, 6.86; F, 3.92; N, 11.56; O, 13.21
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Synonym: P 34081; P-34081; P34081
IUPAC/Chemical Name: Benzenepropanamide, N-(3-fluoro-2-oxo-1-(2-phenylethyl)propyl)-alpha-((((4-morpholinylmethyl)amino)carbonyl)amino)-, (S-(R*,R*))-
InChi Key: HVNUJYRAMGSGJV-GOTSBHOMSA-N
InChi Code: InChI=1S/C26H33FN4O4/c27-18-24(32)22(12-11-20-7-3-1-4-8-20)29-25(33)23(17-21-9-5-2-6-10-21)30-26(34)28-19-31-13-15-35-16-14-31/h1-10,22-23H,11-19H2,(H,29,33)(H2,28,30,34)/t22-,23-/m0/s1
SMILES Code: O=C(N[C@@H](CCC1=CC=CC=C1)C(CF)=O)[C@@H](NC(NCN2CCOCC2)=O)CC3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 484.57 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Perche O, Doly M, Ranchon-Cole I. Calpains are activated by light but their inhibition has no neuroprotective effect against light-damage. Exp Eye Res. 2009 Dec;89(6):989-94. doi: 10.1016/j.exer.2009.08.012. Epub 2009 Sep 1. PubMed PMID: 19729009.
2: Esser RE, Angelo RA, Murphey MD, Watts LM, Thornburg LP, Palmer JT, Talhouk JW, Smith RE. Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis. Arthritis Rheum. 1994 Feb;37(2):236-47. PubMed PMID: 8129779.
3: Rosenthal PJ, Lee GK, Smith RE. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest. 1993 Mar;91(3):1052-6. PubMed PMID: 8450035; PubMed Central PMCID: PMC288059.