M 16287

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584781

CAS#: 128851-55-8

Description: M 16287 is a potent aldose reductase inhibitor.

Chemical Structure

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M 16287
CAS# 128851-55-8
Instruction

Theoretical Analysis

Hodoodo Cat#: H584781
Name: M 16287
CAS#: 128851-55-8
Chemical Formula: C11H7ClN2O5S
Exact Mass: 313.98
Molecular Weight: 314.696
Elemental Analysis: C, 41.98; H, 2.24; Cl, 11.26; N, 8.90; O, 25.42; S, 10.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: M 16287; M16287; M-16287

IUPAC/Chemical Name: 2,4-Imidazolidinedione, 1-((3-chloro-2-benzofuranyl)sulfonyl)-

InChi Key: QYFQMSHWVIKPSY-UHFFFAOYSA-N

InChi Code: InChI=1S/C11H7ClN2O5S/c12-9-6-3-1-2-4-7(6)19-10(9)20(17,18)14-5-8(15)13-11(14)16/h1-4H,5H2,(H,13,15,16)

SMILES Code: O=C1NC(CN1S(=O)(C2=C(Cl)C3=CC=CC=C3O2)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 314.70 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Miwa I, Chen AS, Taguchi T. Glyceraldehyde is present in rat lens and its level is increased in diabetes mellitus. Ophthalmic Res. 2009;41(2):98-101. doi: 10.1159/000187626. Epub 2008 Dec 20. PubMed PMID: 19122471.

2: Kato K, Nakayama K, Ohta M, Murakami N, Murakami K, Mizota M, Miwa I, Okuda J. Effects of novel aldose reductase inhibitors, M16209 and M16287, on streptozotocin-induced diabetic neuropathy in rats. Eur J Pharmacol. 1991 Feb 7;193(2):185-91. PubMed PMID: 1828768.

3: Kato K, Nakayama K, Mizota M, Miwa I, Okuda J. Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil. Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1540-5. PubMed PMID: 1934175.

4: Kato K, Nakayama K, Ohta M, Murakami N, Murakami K, Mizota M, Miwa I, Okuda J. Effects of novel hydantoin derivatives with aldose reductase inhibiting activity on galactose-induced cataract in rats. Jpn J Pharmacol. 1990 Dec;54(4):355-64. PubMed PMID: 2128352.