p38 MAP Kinase Inhibitor IV
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Hodoodo CAT#: H531400

CAS#: 1638-41-1

Description: p38 MAP Kinase Inhibitor IV is an ATP-competitive inhibitor of p38α/β MAPK with IC50 values of 130 nM for p38α and 550 nM for p38β. It is much less active with ≤23% inhibition at 1 μM against p38γ/σ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203580 in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 μM inhibitor). A recent study showed that p38 MAP Kinase Inhibitor IV could consistently and significantly enhance reprogramming and iPS cell generation from somatic cells.


Chemical Structure

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p38 MAP Kinase Inhibitor IV
CAS# 1638-41-1

Theoretical Analysis

Hodoodo Cat#: H531400
Name: p38 MAP Kinase Inhibitor IV
CAS#: 1638-41-1
Chemical Formula: C12H4Cl6O4S
Exact Mass: 453.80
Molecular Weight: 456.920
Elemental Analysis: C, 31.54; H, 0.88; Cl, 46.55; O, 14.01; S, 7.02

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 Weeks
25mg USD 650 2 Weeks
50mg USD 950 2 Weeks
Bulk inquiry

Synonym: p38 MAP Kinase Inhibitor IV

IUPAC/Chemical Name: 2,2′-Sulfonyl-bis-(3,4,6-trichlorophenol)

InChi Key: AKUKHICVNCCQHN-UHFFFAOYSA-N

InChi Code: InChI=1S/C12H4Cl6O4S/c13-3-1-5(15)9(19)11(7(3)17)23(21,22)12-8(18)4(14)2-6(16)10(12)20/h1-2,19-20H

SMILES Code: O=S(C1=C(Cl)C(Cl)=CC(Cl)=C1O)(C2=C(Cl)C(Cl)=CC(Cl)=C2O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 456.92 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mohetaer M, Li G, Wang Y, Cao L. Protective effects of gemigliptin against type II collagen degradation in human chondrocytes. Biomed Pharmacother. 2018 Aug;104:590-594. doi: 10.1016/j.biopha.2018.04.018. Epub 2018 May 25. PubMed PMID: 29803171.

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9: Wang R, Zhang H, Wang Y, Song F, Yuan Y. Inhibitory effects of quercetin on the progression of liver fibrosis through the regulation of NF-кB/IкBα, p38 MAPK, and Bcl-2/Bax signaling. Int Immunopharmacol. 2017 Jun;47:126-133. doi: 10.1016/j.intimp.2017.03.029. Epub 2017 Apr 6. PubMed PMID: 28391159.

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