WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H573496
CAS#: 21492-45-5
Description: AHR-1900 hydrochloride is a butyrophenone derivative used in the treatment of schizophrenia.
Hodoodo Cat#: H573496
Name: AHR-1900 hydrochloride
CAS#: 21492-45-5
Chemical Formula: C21H25ClFNO3
Exact Mass: 393.15
Molecular Weight: 393.880
Elemental Analysis: C, 64.04; H, 6.40; Cl, 9.00; F, 4.82; N, 3.56; O, 12.19
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Synonym: AHR-1900 hydrochloride, AHR-1900 HCl
IUPAC/Chemical Name: 4'-Fluoro-4-(3-(2-methoxyphenoxy)-1-pyrrolidinyl)butyrophenone hydrochloride
InChi Key: VLXVGMDGBFTXOW-UHFFFAOYSA-N
InChi Code: 1S/C21H24FNO3.ClH/c1-25-20-6-2-3-7-21(20)26-18-12-14-23(15-18)13-4-5-19(24)16-8-10-17(22)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
SMILES Code: c1(c(cccc1)OC)O[C@@H]1C[N@@](CCCC(c2ccc(F)cc2)=O)CC1.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 393.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sugerman AA, Herrmann J, O'Hara M. A pilot study of AHR-1900 in chronc schizophrenic patients. Curr Ther Res Clin Exp. 1970 Apr;12(4):234-6. PubMed PMID: 4989873.
2: Gallant DM, Bishop MP. AHR-1900: a butyrophenone derivative. Curr Ther Res Clin Exp. 1969 Dec;11(12):793-5. PubMed PMID: 4984045.
3: Stanley M, Wilk S. The effect of antipsychotic drugs and their clinically inactive analogs on dopamine metabolism. Eur J Pharmacol. 1977 Aug 15;44(4):293-302. PubMed PMID: 19267.
4: Hays SE, Poland RE, Rubin RT. Prolactin releasing potencies of antipsychotic and related nonantipsychotic compounds in female rats: relation to clinical potencies. J Pharmacol Exp Ther. 1980 Aug;214(2):362-7. PubMed PMID: 6104725.