WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558690
CAS#: NONE
Description: C000000956 is a naturally sourced small molecule inhibitor of BACE1.
Hodoodo Cat#: H558690
Name: C000000956
CAS#: NONE
Chemical Formula: C20H18N4
Exact Mass: 314.15
Molecular Weight: 314.390
Elemental Analysis: C, 76.41; H, 5.77; N, 17.82
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Synonym: C-000000956; C 000000956; C000000956
IUPAC/Chemical Name: N3-(3-(1H-Indol-6-yl)benzyl)pyridine-2,3-diamine
InChi Key: LPQUIIHPUGDHJK-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H18N4/c21-20-18(5-2-9-23-20)24-13-14-3-1-4-16(11-14)17-7-6-15-8-10-22-19(15)12-17/h1-12,22,24H,13H2,(H2,21,23)
SMILES Code: NC1=NC=CC=C1NCC2=CC=CC(C3=CC4=C(C=C3)C=CN4)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 314.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Joseph OA, Babatomiwa K, Niyi A, Olaposi O, Olumide I. Molecular Docking and 3D Qsar Studies of C000000956 as a Potent Inhibitor of Bace-1. Drug Res (Stuttg). 2019 Aug;69(8):451-457. doi: 10.1055/a-0849-9377. Epub 2019 Feb 19. PubMed PMID: 30780168.