WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H585079
CAS#: 76674-14-1
Description: R 151885 delays ovulation in rats.
Hodoodo Cat#: H585079
Name: R 151885
CAS#: 76674-14-1
Chemical Formula: C16H13F2N3O
Exact Mass: 301.10
Molecular Weight: 301.297
Elemental Analysis: C, 63.78; H, 4.35; F, 12.61; N, 13.95; O, 5.31
This product is not in stock, which may be available by custom synthesis.
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Synonym: R 151885; R151885; R-151885
IUPAC/Chemical Name: 1H-1,2,4-Triazole-1-ethanol, alpha,alpha-bis(4-fluorophenyl)-
InChi Key: OGZYWIZILQBEJI-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H13F2N3O/c17-14-5-1-12(2-6-14)16(22,9-21-11-19-10-20-21)13-3-7-15(18)8-4-13/h1-8,10-11,22H,9H2
SMILES Code: OC(C1=CC=C(F)C=C1)(C2=CC=C(F)C=C2)CN3N=CN=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 301.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Milne CM, Hasmall RL, Russell A, Watson SC, Vaughan Z, Middleton MC. Reduced estradiol production by a substituted triazole results in delayed ovulation in rats. Toxicol Appl Pharmacol. 1987 Sep 30;90(3):427-35. PubMed PMID: 3310336.
2: Wickings EJ, Middleton MC, Hillier SG. Non-steroidal inhibition of granulosa cell aromatase activity in vitro. J Steroid Biochem. 1987 Jun;26(6):641-6. PubMed PMID: 3112466.
3: Middleton MC, Milne CM, Moreland S, Hasmall RL. Ovulation in rats is delayed by a substituted triazole. Toxicol Appl Pharmacol. 1986 Apr;83(2):230-9. PubMed PMID: 3083533.