WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H573824
CAS#: 30845-11-5
Description: S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine.
Hodoodo Cat#: H573824
Name: S-(3-Carboxypropyl)-L-cysteine
CAS#: 30845-11-5
Chemical Formula: C7H13NO4S
Exact Mass: 207.06
Molecular Weight: 207.240
Elemental Analysis: C, 40.57; H, 6.32; N, 6.76; O, 30.88; S, 15.47
Synonym: S-(3-Carboxypropyl)-L-cysteine
IUPAC/Chemical Name: (R)-4-[(2-Amino-2-carboxyethyl)thio]butanoic Acid
InChi Key: WNFNRNDFHINZLV-YFKPBYRVSA-N
InChi Code: InChI=1S/C7H13NO4S/c8-5(7(11)12)4-13-3-1-2-6(9)10/h5H,1-4,8H2,(H,9,10)(H,11,12)/t5-/m0/s1
SMILES Code: O=C(O)CCCSC[C@H](N)C(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | S-(3-Carboxypropyl)-L-cysteine is a thioether derivative of L-cysteine. |
| In vitro activity: | CPC was a competitive inhibitor with respect to both cystathionine and cysteine in the canonical and H2S synthesis reactions, respectively. The lower Ki value in the cystathionine (50 ± 3 μm) versus cysteine (180 ± 15 μm) cleavage assay suggests that CPC competes more effectively against the longer cystathionine versus the shorter cysteine substrate. The Kd(app) for CPC binding to CSE was 26 ± 3 μm. In cell culture, CPC inhibited the transsulfuration flux, an indicator of the canonical CSE reaction; ≥80% inhibition was observed in HepG2 cells at a concentration of 2.5 mm CPC (Fig. 5A). Reference: J Biol Chem. 2019 Jul 12;294(28):11011-11022. https://pubmed.ncbi.nlm.nih.gov/31160338/ |
| In vivo activity: | TBD |
The following data is based on the product molecular weight 207.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019 Jul 12;294(28):11011-11022. doi: 10.1074/jbc.RA119.009047. Epub 2019 Jun 3. PMID: 31160338; PMCID: PMC6635441. |
| In vitro protocol: | 1. Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019 Jul 12;294(28):11011-11022. doi: 10.1074/jbc.RA119.009047. Epub 2019 Jun 3. PMID: 31160338; PMCID: PMC6635441. |
| In vivo protocol: | TBD |
1: Yadav PK, Vitvitsky V, Kim H, White A, Cho US, Banerjee R. S-3-Carboxypropyl-l-cysteine specifically inhibits cystathionine γ-lyase-dependent hydrogen sulfide synthesis. J Biol Chem. 2019 Jul 12;294(28):11011-11022. doi: 10.1074/jbc.RA119.009047. Epub 2019 Jun 3. PubMed PMID: 31160338; PubMed Central PMCID: PMC6635441.
