XRK3F2
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Hodoodo CAT#: H558760

CAS#: NONE

Description: XRK3F2 is an inhibitor of signaling via the ZZ domain of p62 (Sequestosome 1), blocking tumor necrosis factor (TNF) and multiple myeloma‐induced Gfi1 upregulation, resulting in decreased binding and recruitment of HDAC1 to the RUNX2 promoter in pre‐OBs.

Chemical Structure

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XRK3F2
CAS# NONE
Instruction

Theoretical Analysis

Hodoodo Cat#: H558760
Name: XRK3F2
CAS#: NONE
Chemical Formula: C23H24ClF2NO3
Exact Mass: 0.00
Molecular Weight: 435.896
Elemental Analysis: C, 63.38; H, 5.55; Cl, 8.13; F, 8.72; N, 3.21; O, 11.01

Price and Availability

Size Price Availability Quantity
5mg USD 280
10mg USD 440
50mg USD 970
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Synonym: XRK-3F2; XRK 3F2; XRK3F2

IUPAC/Chemical Name: 2-[[3,4-Bis[(4-fluorophenyl)methoxy]phenyl]methylamino]ethanol hydrochloride

InChi Key: XBSQIUHKVROJDN-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H23F2NO3.ClH/c1-26(12-13-27)21-10-11-22(28-15-17-2-6-19(24)7-3-17)23(14-21)29-16-18-4-8-20(25)9-5-18;/h2-11,14,27H,12-13,15-16H2,1H3;1H

SMILES Code: CN(CCO)C1=CC=C(OCC2=CC=C(F)C=C2)C(OCC3=CC=C(F)C=C3)=C1.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 435.90 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Adamik J, Silbermann R, Marino S, Sun Q, Anderson JL, Zhou D, Xie XQ, Roodman GD, Galson DL. XRK3F2 Inhibition of p62-ZZ Domain Signaling Rescues Myeloma-Induced GFI1-Driven Epigenetic Repression of the Runx2 Gene in Pre-osteoblasts to Overcome Differentiation Suppression. Front Endocrinol (Lausanne). 2018 Jun 29;9:344. doi: 10.3389/fendo.2018.00344. eCollection 2018. PubMed PMID: 30008697; PubMed Central PMCID: PMC6033965.

2: Teramachi J, Silbermann R, Yang P, Zhao W, Mohammad KS, Guo J, Anderson JL, Zhou D, Feng R, Myint KZ, Maertz N, Beumer JH, Eiseman JL, Windle JJ, Xie XQ, Roodman GD, Kurihara N. Blocking the ZZ domain of sequestosome1/p62 suppresses myeloma growth and osteoclast formation in vitro and induces dramatic bone formation in myeloma-bearing bones in vivo. Leukemia. 2016 Feb;30(2):390-8. doi: 10.1038/leu.2015.229. Epub 2015 Aug 19. PubMed PMID: 26286116; PubMed Central PMCID: PMC4740189.