WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532720
CAS#: 1043110-13-9
Description: E09241 is a novel OPG/RANKL upregulator, increasing OPG expression without affecting RANKL expression, promoting osteoblast differentiation while inhibiting osteoclast differentiation, regulating OPG expression through canonical Wnt/β-catenin signaling.
Hodoodo Cat#: H532720
Name: E09241
CAS#: 1043110-13-9
Chemical Formula: C11H9ClN2O2
Exact Mass: 236.04
Molecular Weight: 236.655
Elemental Analysis: C, 55.83; H, 3.83; Cl, 14.98; N, 11.84; O, 13.52
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Synonym: E09241; E-09241; E 09241;
IUPAC/Chemical Name: 5-Chloro-N-(4-methylpyridin-2-yl)furan-2-carboxamide
InChi Key: XUZSJAATNRKRPD-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H9ClN2O2/c1-7-4-5-13-10(6-7)14-11(15)8-2-3-9(12)16-8/h2-6H,1H3,(H,13,14,15)
SMILES Code: O=C(C1=CC=C(Cl)O1)NC2=NC=CC(C)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 236.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Han X, Gong S, Li N, Wang X, Liu P, Xu Y, He X, Jiang W, Si S. A Novel Small
Molecule Which Increases Osteoprotegerin Expression and Protects Against
Ovariectomy-Related Bone Loss in Rats. Front Pharmacol. 2019 Mar 11;10:103. doi:
10.3389/fphar.2019.00103. eCollection 2019. PubMed PMID: 30914947; PubMed Central
PMCID: PMC6421503.