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O304
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H555641

CAS#: 1261289-04-6

Description: O-304 is a pan-activator of AMP-activated protein kinase (AMPK). It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients.

Chemical Structure

O304

CAS# 1261289-04-6

Instruction

Theoretical Analysis

Hodoodo Cat#: H555641
Name: O304
CAS#: 1261289-04-6
Chemical Formula: C16H11Cl2N3O2S
Exact Mass: 378.99
Molecular Weight: 380.243
Elemental Analysis: C, 50.54; H, 2.92; Cl, 18.65; N, 11.05; O, 8.42; S, 8.43

Price and Availability

Size	Price	Availability
100mg	USD 950	2 Weeks
200mg	USD 1450	2 Weeks
500mg	USD 2950	2 Weeks
1g	USD 4250	2 Weeks
2g	USD 6950	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: O-304; O 304; O304;

IUPAC/Chemical Name: 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-benzamide

InChi Key: WEDWLYRQKUTOAX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23)

SMILES Code: O=C(NC(SN1CC2=CC=C(Cl)C=C2)=NC1=O)C3=CC=C(Cl)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 380.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Das V, Kroin JS, Moric M, McCarthy RJ, Buvanendran A. AMP-activated protein kinase (AMPK) activator drugs reduce mechanical allodynia in a mouse model of low back pain. Reg Anesth Pain Med. 2019 Sep 20. pii: rapm-2019-100839. doi: 10.1136/rapm-2019-100839. [Epub ahead of print] PubMed PMID: 31541009.

2: Das V, Kroin JS, Moric M, McCarthy RJ, Buvanendran A. Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain. Reg Anesth Pain Med. 2019 Jun 21. pii: rapm-2019-100651. doi: 10.1136/rapm-2019-100651. [Epub ahead of print] PubMed PMID: 31229963.

3: D'Souza N, Balyasnikova S, Tudyka V, Lord A, Shaw A, Abulafi M, Tekkis P, Brown G. Variation in landmarks for the rectum: an MRI study. Colorectal Dis. 2018 Oct;20(10):O304-O309. doi: 10.1111/codi.14398. Epub 2018 Sep 26. PubMed PMID: 30176118.

4: Steneberg P, Lindahl E, Dahl U, Lidh E, Straseviciene J, Backlund F, Kjellkvist E, Berggren E, Lundberg I, Bergqvist I, Ericsson M, Eriksson B, Linde K, Westman J, Edlund T, Edlund H. PAN-AMPK activator O304 improves glucose homeostasis and microvascular perfusion in mice and type 2 diabetes patients. JCI Insight. 2018 Jun 21;3(12). pii: 99114. doi: 10.1172/jci.insight.99114. eCollection 2018 Jun 21. PubMed PMID: 29925691; PubMed Central PMCID: PMC6124394.

5: Riad NM, Zlotos DP, Holzgrabe U. Crystal structure of 5,11-di-hydro-pyrido[2,3-b][1,4]benzodiazepin-6-one. Acta Crystallogr E Crystallogr Commun. 2015 Apr 11;71(Pt 5):o304-5. doi: 10.1107/S2056989015006817. eCollection 2015 May 1. PubMed PMID: 25995917; PubMed Central PMCID: PMC4420050.

6: Ohno K, Fujihara T, Nagasawa A. An ortho-rhom-bic polymorph of N (1),N (4)-diphenyl-3,6-bis-(phenyl-imino)-cyclo-hexa-1,4-diene-1,4-di-amine. Acta Crystallogr Sect E Struct Rep Online. 2014 Mar 29;70(Pt 4):o495-6. doi: 10.1107/S1600536814006254. eCollection 2014 Apr 1. PubMed PMID: 24826185; PubMed Central PMCID: PMC3998558.

7: Yoon YK, Ali MA, Tan SC, Rosli MM, Razak IA. 3-{5-Eth-oxy-carbonyl-1-[3-(2-oxopyrrol-idin-1-yl)prop-yl]-1H-benzimidazol-2-yl}b enzoic acid. Acta Crystallogr Sect E Struct Rep Online. 2013 Feb 1;69(Pt 2):o304. doi: 10.1107/S1600536813001116. Epub 2013 Jan 31. PubMed PMID: 23424569; PubMed Central PMCID: PMC3569823.

8: Yu Y. 7-Chloro-6,8-dinitro-quinazolin-4(3H)-one acetic acid monosolvate. Acta Crystallogr Sect E Struct Rep Online. 2012 Feb 1;68(Pt 2):o304. doi: 10.1107/S1600536811055735. Epub 2012 Jan 7. PubMed PMID: 22346942; PubMed Central PMCID: PMC3274997.

9: Loh WS, Fun HK, Sarveswari S, Vijayakumar V, Reddy BP. 6-Chloro-3-[5-(4-fluoro-phen-yl)-1-phenyl-4,5-dihydro-1H-pyrazol-3-yl]-2-methyl-4 -phenyl-quinoline. Acta Crystallogr Sect E Struct Rep Online. 2010 Jan 9;66(Pt 2):o304. doi: 10.1107/S1600536810000218. PubMed PMID: 21579737; PubMed Central PMCID: PMC2979872.

10: Zhang M, Yuan XY, Liu XM. 2,2-Dimethyl-5-triphenyl-methyl-1,3-dioxane. Acta Crystallogr Sect E Struct Rep Online. 2009 Jan 14;65(Pt 2):o304. doi: 10.1107/S1600536809000294. PubMed PMID: 21581913; PubMed Central PMCID: PMC2968387.

11: Portalone G, Colapietro M. Nicotinohydrazide. Acta Crystallogr Sect E Struct Rep Online. 2007 Dec 18;64(Pt 1):o304. doi: 10.1107/S1600536807066561. PubMed PMID: 21200868; PubMed Central PMCID: PMC2915352.

12: Batsanov AS, Goeta AE, Howard JA, Soto B, Au-Alvarez O. 2-(4-Chloroanilino)- and 2-(4-methoxyanilino)-1,2-diphenylethanone. Acta Crystallogr C. 2006 May;62(Pt 5):o304-6. Epub 2006 Apr 29. PubMed PMID: 16679611.

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